藏药复方红景天滴丸浓缩工艺稳定性研究  

Study on the Stability of the Concentration Process of Compound Rhodiolae Crenulatae Radix et rhizoma Dropping Pills

作　　者：赵琪 石倩 省布么你呷 刘馨安 赖先荣[2] ZHAO Qi;SHI Qian;SHENGBU Me'ni'ga;LIU Xin'an;LAI Xianrong(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan;School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan)

机构地区：[1]西南特色中药资源国家重点实验室,成都中医药大学药学院,四川成都611137 [2]成都中医药大学民族医药学院,四川成都611137

出　　处：《中药与临床》2024年第6期38-41,共4页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省中医药管理局项目(2024MS046)。

摘　　要：目的:研究复方红景天滴丸中指标性成分没食子酸、红景天苷、甘草酸铵在浓缩过程中的稳定性,制定浓缩工艺参数。方法:建立指标成分的含量测定方法,考察60~90℃时常压和减压浓缩状态下复方红景天滴丸的热稳定性规律,确定复方的浓缩工艺参数并进行验证。结果:两种浓缩方式对指标性成分的含量影响相近,但红景天苷在70℃以上浓缩时转移率相对较低,减压浓缩6 h过程中,没食子酸、红景天苷、甘草酸铵的转移率保持稳定。结合实际生产,初步确定复方红景天滴丸的浓缩工艺为减压浓缩。结论:复方红景天滴丸浓缩过程中没食子酸、红景天苷、甘草酸铵均无明显的热敏性,减压浓缩的工艺条件合理、可行。Objective:To study the stability of gallic acid,salidroside and ammonium glycyrrhizin in the concentration process of Compound Rhodiolae Crenulatae Radix et rhizoma Dropping Pills,and to formulate the concentration process parameters.Methods:The method for determining the content of the index components was established.The thermal stability of Compound Rhodiolae Crenulatae Radix et rhizoma Dropping Pills under constant pressure concentration at 60~90℃was investigated.The concentration process parameters of the compound was determined and verified.Results:The two concentration methods had similar effects on the content of the index components,but the transfer rate of salidroside was relatively low when concentrated above 70℃,and the transfer rate of gallic acid,salidroside and ammonium glycyrrhizinate remained stable during the concentration process of 6 h under reduced pressure.According to the actual production,the concentration technology of Compound Rhodiolae Crenulatae Radix et Rhizoma Dropping Pills was determined to be reduced pressure concentration.Conclusion:Gallic acid,salidroside and ammonium glycyrrhizin have no obvious heat sensitivity during the concentration of Compound Rhodiolae Crenulatae Radix et rhizoma Dropping Pills,and the process conditions of atmospheric pressure concentration are reasonable and feasible.

关 键 词：没食子酸 红景天苷 甘草酸铵 高效液相色谱系统法 常压浓缩 减压浓缩 热稳定性 

分 类 号：R284.1[医药卫生—中药学]