同步放化疗联合诱导化疗治疗局部晚期非小细胞肺癌患者疗效及其对血清血管内皮生长因子、免疫功能和生存质量的影响  

Efficacy of combined induction chemotherapy and concurrent chemoradiotherapy in treating locally advanced non-squamous cell lung cancer and its influence on serum vascular endothelial growth factor,immune function and quality of life

作　　者：崔莹[1] 王冰心 郭琳[2] 高炜[3] Cui Ying;Wang Bingxin;Guo Lin;Gao Wei(Second department of radiotherapy,Qingdao Cancer Hospital Affiliated to Qingdao University,Qingdao 266042,China;不详)

机构地区：[1]青岛大学附属青岛市肿瘤医院放疗二科,山东青岛266042 [2]青岛大学附属青岛市肿瘤医院妇瘤科,山东青岛266042 [3]青岛大学附属青岛市肿瘤医院肿瘤内三科,山东青岛266042

出　　处：《临床内科杂志》2024年第11期747-750,共4页Journal of Clinical Internal Medicine

摘　　要：目的探讨同步放化疗联合诱导化疗治疗局部晚期非小细胞肺癌(NSCLC)患者的疗效及其对血清血管内皮生长因子、免疫功能和生存质量的潜在影响。方法将80例局部晚期NSCLC患者,用区组随机化分组法分为对照组和观察组,每组各40例。对照组接受同步放化疗,观察组在对照组基础上联合诱导化疗治疗。比较两组患者治疗效果、血管生成素[内皮细胞增生因子(VEGF)、PLT源性生长因子(PDGF)、成纤维细胞增生因子(FGF)]、免疫功能(IgG、IgM、IgA),生存质量[欧洲癌症研究组肺癌特定生存质量问卷(QLQ-LC13)评分],并通过Kaplan-Meier曲线分析两组无进展生存及总生存情况。结果治疗后,观察组患者总缓解率显著高于对照组(P<0.05)。与同组治疗前比较,两组患者VEGF、PDGF、FGF、IgG、IgM、IgA水平及QLQ-LC13评分均降低;治疗后,观察组患者上述指标均显著低于同期对照组(P<0.05)。观察组无进展生存时间和总生存时间均显著长于对照组(P<0.05)。结论对局部晚期NSCLC患者,同步放化疗联合诱导化疗治疗效果显著,有助于抑制肿瘤扩散、调节免疫功能,从而提高患者生存质量,对延长患者生存时间有积极意义。Objective To investigate the efficacy of combining induction chemotherapy with concurrent chemoradiotherapy in the treatment of patients diagnosed with locally advanced non-squamous cell lung cancer(NSCLC),and evaluating its possible impacts on serum vascular endothelial growth factor,immune function and quality of life.Methods 80 patients with locally advanced NSCLC were divided into control group and observation group through random assignment,40 cases in each group.Control group underwent concurrent chemoradiotherapy,and observation group underwent with induction chemotherapy based on the treatment regimen of the control group.The therapeutic effect,vascular endothelial growth factor[factor for vascular endothelial growth(VEGF),growth gactor derived from platelets(PDGF),growth factor for fibroblasts(FGF)],immune function(IgG,IgM,IgA)and quality of life[European Cancer Research Group lung cancer specific quality of life questionnaire(QLQ-LC13)score]were compared among the two groups,and the progression-free survival and overall survival in the two groups were analyzed by Kaplan-Meier curve.Results After treatment,the total remission rate in the observation group was significantly higher than that in control group(P<0.05).Compared with those before treatment in the same group,the levels of VEGF,PDGF,FGF,IgG,IgM,IgA and the scores of QLQ-LC13 questionnaire in both the observation group and the control group decreased(P<0.05).Compared with control group in the same period,the above indicators in observation group were significantly lower than those in control group(P<0.05).The progression-free survival time and overall survival time in observation group were significantly longer than those in control group.Conclusion Combined concurrent chemoradiotherapy induction chemotherapy can achieve significant efficacy for patients diagnosed with locally advanced non-squamous cell lung cancer,and it can help to stop the spread of tumor,regulate the immune function and enhance the quality of life of patients,and it has posit

关 键 词：同步放化疗 诱导化疗 局部晚期非小细胞肺癌 血清血管生成素 

分 类 号：R734.2[医药卫生—肿瘤]