Progress on the mechanism of food polyphenols in the prevention of liver fi brosis  

作　　者：Jianye Dai Man Zhang Yipeng Wang Jiaoying Liu Junyan Shan Guangyue Su 

机构地区：[1]Faculty of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Journal of Polyphenols》2024年第4期150-164,共15页多酚杂志（英文）

基　　金：supported by the People’s Livelihood Plan Project of Department of Science and Technology of Liaoning Province(No.2021JH2/10300074);Department of Education of Liaoning Province(No.LJKMZ20221367);Career Development Support Plan for Young and Middleaged Teachers in Shenyan。

摘　　要：Liver fibrosis is the formation of extracellular matrix deposits due to excessive repair of chronic liver damage.Liver fi brosis is a necessary stage in the progression of cirrhosis,and timely intervention reverses the pathogenesis.Liver fi brosis is a dynamic and highly integrated molecular,cellular and organisational process.Currently,no specifi c drug is used to treat liver fi brosis,and liver transplantation is the main clinical treatment for cirrhosis.Chemical drugs are often designed to target individual genes or proteins,with kinds of side eff ects.Food polyphenols,which are available and safe,have unique advantages and great potential in the treatment with the liver fibrosis.This review summarizes the pathogenesis of liver fi brosis and provides examples of food polyphenols’anti-liver fi brosis mechanisms that have been identifi ed in recent studies,and provides some sights for the development of anti-liver fi brosis drugs.

关 键 词：food polyphenols liver fi brosis MECHANISM 

分 类 号：R575.2[医药卫生—消化系统]