基于环境响应原位凝胶基质的研究进展  

Research progress on in situ gel matrix based on environmental response

作　　者：万军[1] 李鑫鑫 陈晨 张鹭 杨祁懿 范依霖 周霞[1] WAN Jun;LI Xinxin;CHEN Chen;ZHANG Lu;YANG Qiyi;FAN Yilin;ZHOU Xia(School of Life Science&Engineering,Southwest Jiaotong University,Chengdu,Sichuan,610031 P.R.China)

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《华西药学杂志》2024年第6期727-732,共6页West China Journal of Pharmaceutical Sciences

基　　金：四川省科技计划重点研发项目(2024YFFK0163);中央高校基本科研业务费专项资金(202310613071);西南交通大学个性化实验项目(GX202316023)。

摘　　要：原位凝胶又称即型凝胶,是一种具有环境敏感性的载药系统,可分为温度敏感型、pH敏感型、离子敏感型等,制备材料也不同。凝胶的性能与凝胶类型、基质种类相关。通过查阅分析文献,总结了不同基质在原位凝胶制剂中的应用情况,包括壳聚糖、泊洛沙姆、结冷胶等,并指出存在的问题,为相关制剂研发提供了参考。The in situ gel is an environmentally sensitive drug delivery system.It can be categorized as thermo-sensitive,pH-sensitive,and ion-sensitive with different materials.The performance of the gel is not only closely related to the type of gel but also influenced by the type of matrix.This review summarizes the application of different matrices in the development of in situ gel formulations,including chitosan,poloxamer,and gellan gum,and points out the issues related to gel types and matrices,providing references and insights for the development of related formulations.

关 键 词：原位凝胶 胶凝机理 壳聚糖 泊洛沙姆 卡波姆 蚕丝蛋白 海藻酸钠 结冷胶 

分 类 号：R94[医药卫生—药剂学]