精神分裂症患者血清非酶类抗氧化物水平分析  

Analysis of serum levels of non-enzymatic antioxidants in patients with schizophrenia

作　　者：俞美红 张平[1] YU Meihong;ZHANG Ping(DepartmentⅠof Psychiatry,Shanghai Fengxian District Mental Health Centre,Shanghai 201418,China)

机构地区：[1]上海市奉贤区精神卫生中心精神Ⅰ科,上海201418

出　　处：《上海医药》2024年第21期48-52,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：上海市奉贤区科学技术委员会基金项目(20201614)。

摘　　要：目的:分析住院精神分裂症患者在治疗期间血清非酶类抗氧化物浓度的动态变化。方法:对133名住院的精神分裂症患者作为观察组,分别检测不同时间节点非酶类抗氧化物浓度,并对比不同年龄层非酶类抗氧化物的浓度,同时将120名健康居民作为对照进行对比。结果:组间对比,观察组入院时血清总胆红素(TBil)浓度和尿酸(UA)浓度均高于对照组,治疗4周和治疗8周后的TBil和UA浓度均低于对照组(P<0.05);治疗8周后的白蛋白(ALB)浓度低于对照组(P<0.05),入院时和治疗4周后的ALB浓度与对照组比较差异无统计学意义。组内对比,观察组治疗4周和治疗8周后的TBil和UA浓度均低于入院时(P<0.05)。40~50岁患者入院时和治疗4周后的ALB浓度低于18~28岁和29~39岁患者(P<0.05);其余指标在不同年龄段的差异无统计学意义。结论:治疗前,精神分裂症患者处于高度氧化应激状态,经过治疗后,患者整体抗氧化能力低于健康人群,需要坚持治疗;高年龄层的患者,其抗氧化能力更弱,更应坚持规范治疗,改善整体预后。Objective:To analyze the dynamic changes in serum non-enzymatic antioxidant concentrations in hospitalized patients with schizophrenia during the treatment.Methods:One hundred and thirty-three cases of the hospitalized patients with schizophrenia were selected as an observation group and the concentrations of their non-enzymatic antioxidant at different time points were determined and compared with those in different age subgroups and 120 healthy residents taken as a controls group.Results:In terms of comparison between groups,the concentrations of serum total bilirubin(TBil)and uric acid(UA)were higher in the observation group than the control group at the time of admission,and were lower in the observation group than the control group after 4 or 8 weeks of treatment(P<0.05).The concentrations of albumin(ALB)were lower in the observation group than the control group after 8 weeks of treatment(P<0.05),and there were no significant differences in ALB concentrations between the two groups at admission and after 4 weeks.In terms of intra-group comparison,the concentrations of TBil and UA in the observation group were all lower at 4 or 8 weeks of treatment than at admission(P<0.05).The ALB concentration of patients aged 40-50 years was lower than that of patients aged 18-28 years and 29-39 years at admission and after 4 weeks of treatment(P<0.05),and the of the rest of the indexes there were no statistically significant differences in the rest of the indicators among the different age groups.Conclusion:Before treatment,patients with schizophrenia were in a state of high oxidative stress;after treatment,the overall antioxidant capacity of the patients was lower than that of the healthy population,and they needed to adhere to the treatment.Patients in the older age groups,whose antioxidant capacity was even weaker,should adhere to the standardized treatment even more to improve the overall prognosis.

关 键 词：精神分裂症 非酶类抗氧化物 年龄 

分 类 号：R749.3[医药卫生—神经病学与精神病学]