香砂六君丸预防吡咯替尼相关脾胃气虚型腹泻疗效观察  

Effect of Xiangsha Liujun Pills on preventing pyrotinib-induced diarrhea in HER2-positive advanced breast cancer patients of spleen and stomach qi deficiency

作　　者：方琛 温嘉槐 黎俊鸿 任黎萍 FANG Chen;WEN Jiahuai;LI Junhong;REN Liping(Second Department of Breast,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510120)

机构地区：[1]广州中医药大学第二附属医院乳腺二科,广东广州510120

出　　处：《河北中医》2024年第12期1960-1963,1968,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20225015)。

摘　　要：目的观察香砂六君丸预防吡咯替尼相关脾胃气虚型腹泻的效果。方法选取67例拟使用吡咯替尼的乳腺癌患者,其中45例未经任何预防性干预(未干预组),22例使用香砂六君丸预防(预防组),随访记录患者用药后出现腹泻相关情况。结果预防组的腹泻发生率为95.5%,未干预组腹泻发生率为100%。预防组中多为1级或2级腹泻,而未干预组以3级腹泻为主(P=0.020)。未干预组中有28.9%患者腹泻超过3个月,而预防组则未有腹泻超过3个月的病例(P=0.007)。预防组22.7%患者由于因为腹泻停药,未干预组53.3%患者因腹泻停药,明显高于预防组(P=0.044)。结论香砂六君丸对服用吡咯替尼的乳腺癌患者进行预防用药,可降低腹泻发生率、腹泻严重程度及腹泻持续时间,对提高生活质量及治疗依从性都有积极意义。Objective To evaluate the effect of Xiangsha Liujun Pills on preventing pyrotinib-induced diarrhea in HER2-positive advanced breast cancer(ABC)patients of spleen and stomach qi deficiency.Methods HER2-positive ABC patients scheduled to receive pyrotinib treatment were screened and finally 67 patients with spleen and stomach qi deficiency syndrome were enrolled.Forty-five cases received no traditional Chinese medicine(TCM)preventive intervention(control group)and the remaining 22 patients coadministrated Xiangsha Liujun Pills with pyrotinib daily(intervention group).The defecation status(character,frequency)of all participants were recorded and the primary endpoint was incidence of any-grade diarrhea.Results The overall diarrhea rate of intervention group and control group were 95.5%and 100%respectively.Majority of cases in the intervention group experienced mild diarrhea(gradeⅠorⅡ),while patients in the control group suffered significantly higher rate of grade 3 diarrhea(P=0.020).Approximately 28.9%of ABC patients in the control group suffered more than 3 months of diarrhea,while no cases in the intervention group experienced long-term diarrhea(P=0.007).Transient pyrotinib interruption due to diarrhea occurred among 22.7%of patients in the intervention group and 53.3%of patients in the control group(P=0.044).Conclusion Prophylactic administration of Xiangsha Liujun Pills could remarkably decrease the occurrence risk,reduce the severity,shorten the duration of diarrhea,and increase quality of life and treatment compliance in patients received pyrotinib treatment.

关 键 词：乳腺癌 吡咯替尼 腹泻 

分 类 号：R737.9[医药卫生—肿瘤]