CRHR2在炎症性肠病中的研究进展  

Progress in research of corticotropin-releasing hormone receptor 2 in inflammatory bowel disease

作　　者：刘浏 金怡丹 范一宏[1] Liu Liu;Yi-Dan Jin;Yi-Hong Fan(Department of Gastroen-terology,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310000,Zhejiang Province,China)

机构地区：[1]浙江中医药大学附属第一医院消化内科,浙江省杭州市310000

出　　处：《世界华人消化杂志》2024年第10期742-749,共8页World Chinese Journal of Digestology

基　　金：浙江省中医药科技计划,No.2022ZB129;浙江省医药卫生科技计划项目,No.2023KY864.

摘　　要：肾上腺皮质激素释放激素家族成员及其受体广泛分布于中枢及外周组织,参与机体心血管、代谢、免疫反应和炎症等方面的调节.促肾上腺皮质激素释放激素受体2(corticotropin-releasing hormone receptor 2,CRHR2)为其特异性受体之一,它可以缓冲应激导致的肠道高敏感性、影响肠道微生物组成和多样性、具有很强的抗炎能力,同时还可以调节肠上皮细胞的增殖和凋亡过程,促进肠粘膜修复.近年来研究表明,在炎症性肠病(inflammatory bowel disease,IBD)患者的结肠组织中检测到CRHR2的含量与正常人体肠道组织存在明显差异,有人认为CRHR2可能是潜在的IBD治疗靶点.本文对CRHR2的生理功能及其与IBD之间的临床相关性进行综述,旨在探索CRHR2在IBD治疗中的具体作用机制和潜在的临床应用价值,为将来开发更多有效的IBD的治疗手段提供依据.Members of the corticotropin-releasing hormone family and their receptors are widely distributed in central and peripheral tissues and are involved in the regulation of the cardiovascular system,metabolism,immune function,and inflammatory response in the body.Corticotropin-releasing hormone receptor 2(CRHR2),one of specific receptors for corticotropin releasing factor,attenuates stress-induced intestinal hypersensitivity,influences intestinal microbial composition and diversity,has strong anti-inflammatory capacity,and regulates the proliferation,migration,and apoptosis of intestinal epithelial cells,and promotes intestinal mucosal repair.In recent years,studies have shown that the levels of CRHR2 in the colon tissue of patients with inflammatory bowel disease(IBD)are significantly different from those in normal human intestinal tissue,and it has been suggested that CRHR2 may be a potential therapeutic target for IBD.This paper reviews the physiological functions of CRHR2 and its clinical relevance to IBD,with the aim of exploring its specific mechanism of action and potential clinical application in the treatment of IBD,so as to provide a basis for the development of more effective therapeutic means for IBD in the future.

关 键 词：炎症性肠病 促肾上腺皮质激素释放激素受体2 肠道微生物 丘脑-垂体-肾上腺轴 

分 类 号：R574[医药卫生—消化系统]