Porphyrin-based metal-organic frameworks for cancer theranostics  

作　　者：Liandi Guan Fang Liu Cun Zhang Wei Wang Jianwei Zhang Qionglin Liang 

机构地区：[1]School of Environmental Science and Engineering,Qingdao University,Qingdao 266071,China [2]MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Department of Chemistry,Laboratory of Flexible Electronics Technology,Center for Synthetic and Systems Biology,Tsinghua University,Beijing 100084,China [3]Department of Pathology,The Affiliated Hospital of Qingdao University,Qingdao 266071,China

出　　处：《Advanced Sensor and Energy Materials》2024年第4期50-79,共30页先进传感器与能源材料（英文）

基　　金：financially supported by Startup Foundation for Advanced Talents of Qingdao University(DC2400001387);National Natural Science Foundation of China(22074157);National Key R&D Program of China(2022YFA1103403);China Postdoctoral Science Foundation(2020M673541);Startup Foundation for Advanced Talents of Qingdao University(DC2100004477);State Key Laboratory of Bio-Fibers and Eco-Textiles of Qingdao University(RZ2200002491).

摘　　要：Theranostics,integrating diagnostic and therapeutic functionalities,have emerged as advanced systems for timely cancer diagnosis and effective treatment.The development of versatile materials suitable for cancer theranostics is intensifying.Porphyrin-based metal-organic frameworks(MOFs)leverage the structural diversity and designability inherent in MOFs,alongside the robust photophysical,catalytic,and biological properties of porphyrins.These materials enhance the solubility and stability of porphyrins and facilitate their stable functionalized assemblies,conferring the potential for multimodal imaging diagnostics and precision therapeutics.In this review,we summarized the potential of porphyrin-based MOFs as cancer theranostics platforms,focusing on recent advancements in porphyrin-based MOFs,and highlighting their functionalized strategies and developments in diagnostic imaging and synergistic therapies.Finally,we proposed the challenges and prospects of these emerging materials in cancer theranostics.

关 键 词：Cancer theranostics Porphyrin-based metal-organic frameworks Multifunctional strategy Diagnosis imaging Enhanced photodynamic therapy Synergistic therapy 

分 类 号：R73[医药卫生—肿瘤]