妊娠中期中性粒细胞淋巴细胞比值与子痫前期的关联性  

Correlation of neutrophil lymphocyte ratio with preeclampsia in the second trimester of pregnancy

作　　者：李玉婷 陈雁丽 刘婵[2] 王凤鸽 刘淼[2] 满冬梅[2] LI Yuting;CHEN Yanli;LIU Chan;WANG Fengge;LIU Miao;MAN Dongmei(Clinic Medical College,Jining Medical University,Jining 272013,China;Department of Obstetrics,Affiliated Hospital of Jining Medical University,Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,济宁272013 [2]济宁医学院附属医院产科,济宁272029

出　　处：《济宁医学院学报》2024年第6期490-493,共4页Journal of Jining Medical University

基　　金：国家自然科学基金(82201876);山东省自然科学基金-青年基金(ZR2021QH114);山东省自然科学基金-联合基金(ZR2021LZY001);中国博士后科学基金(2023M731307);济宁医学院附属医院博士后项目(322155);济宁医学院贺林院士新医学临床转化工作站科研基金项目(JYHL2021MS24);济宁医学院高层次科研项目培育计划(JYGC2021KJ007);济宁市重点研发项目(2023YXNS070)。

摘　　要：目的探究妊娠中期中性粒细胞/淋巴细胞比值(NLR)在轻度子痫前期、重度子痫前期及健康孕妇之间的差异关系,以及NLR在子痫前期筛查中潜在的预测价值。方法选取了2018年1月1日至2021年1月30日在济宁医学院附属医院就诊的所有孕妇1115例,其中轻度子痫前期395例,重度子痫前期339例,正常妊娠孕妇381例。同时,收集患者年龄、BMI、外周血NLR、收缩压及舒张压等资料,探究子痫前期与NLR的关系。结果轻/重度子痫前期组外周血中NLR数值均高于正常妊娠组,并且重度子痫前期组NLR高于轻度子痫前期组(P<0.001),在调整BMI、年龄、血压等变量因素后,发现NLR仍是子痫前期的独立危险因素(OR=2.814,95%CI=2.130~3.717)。结论妊娠中期外周血的NLR增高是子痫前期的独立危险因素。因此,NLR对子痫前期的发生可能具有预测作用。Objective To investigate the differential relationship between neutrophil/lymphocyte ratio(NLR)in mild preeclampsia,severe preeclampsia and healthy pregnant women in the second trimester,and the potential value of NLR in screening for preeclampsia and predicting the severity of its disease development.Methods A total of 1115 pregnant women were selected from the Affiliated Hospital of Jining Medical University from January 1,2018 to January 30,2021,including 395 cases of mild preeclampsia and 339 cases of severe preeclampsia,and 381 cases of normal pregnant women hospitalized.At the same time,the patient′s age,BMI,peripheral blood NLR,systolic and diastolic blood pressure were collected to explore the relationship between preeclampsia and NLR.Results NLR in peripheral blood of preeclampsia pregnant women(including mild and severe preeclampsia pregnant women)was significantly higher than that of healthy pregnant women.Moreover,NLR was significantly higher in patients with severe preeclampsia than in patients with mild preeclampsia(P<0.001).After adjusting for variables such as BMI,age,and blood pressure,NLR was still found to be an independent risk factor for preeclampsia(OR=2.814,95%CI=2.130~3.717).Conclusion The increase of NLR in peripheral blood during the second trimester of pregnancy is an independent risk factor for preeclampsia.Therefore,NLR may be predictive of the occurrence of preeclampsia.

关 键 词：子痫前期 中性粒细胞/淋巴细胞 妊娠中期 疾病预测 

分 类 号：R179[医药卫生—妇幼卫生保健]