脊索瘤分子诊断及治疗的研究进展  

Research progress in molecular diagnosis and treatment of chordoma

作　　者：王斌 张亚中 汤中建 朱哲希 白津 WANG Bin;ZHANG Yazhong;TANG Zhongjian;ZHU Zhexi;BAI Jin(Department of Orthopedics,the Second Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China;Xuzhou Medical University,Xuzhou,Jiangsu 221004)

机构地区：[1]徐州医科大学第二附属医院骨科,江苏徐州221002 [2]徐州医科大学,江苏徐州221004

出　　处：《徐州医科大学学报》2024年第11期781-786,共6页Journal of Xuzhou Medical University

基　　金：国家自然科学基金(82072649);徐州市科技项目(KC21058);彭城英才徐州市青年医学后备人才项目(XWRCHT20220024)。

摘　　要：脊索瘤作为一种恶性程度较高的原发恶性肿瘤,起源于胚胎残余脊索组织,复发率高,预后差。目前相关研究已经发现包括Brachyury基因等多个分子及信号通路参与脊索瘤的发生发展,但其病因仍不明确。由于脊索瘤转移率高且对周围组织侵袭性较强,其治疗仍是目前亟待解决的一大难题。研究脊索瘤发生发展的关键分子及信号通路不仅有助于深入了解脊索瘤的发病机制,也为改善脊索瘤治疗现状提供了新的方向。本文从脊索瘤的分子信号学、临床诊断及治疗等方面对脊索瘤的研究进展进行论述。Chordoma,as a highly malignant primary tumor,originates from residual embryonic spinal cord tissue,with a high recurrence rate and poor prognosis.Although current research has found that multiple molecules and signaling pathways,including the Brachyury gene,are involved in the occurrence and development of spinal cord tumors,their etiology is still unclear.Due to the strong metastasis and invasion of surrounding tissues,the treatment of spinal cord tumors remains a major challenge that urgently needs to be addressed.Identifying the key molecules and signaling pathways involved in the occurrence and development of spinal cord tumors can not only help to gain a deeper understanding of the pathogenesis of spinal cord tumors,but also provide new directions for improving the current status of spinal cord tumor treatment.This article reviews the research progress of chordoma from the aspects of molecular signaling,clinical diagno-sis and treatment.

关 键 词：脊索瘤 骨肿瘤 分子生物学 信号通路 治疗 手术 

分 类 号：R738.1[医药卫生—肿瘤]