血清GP73、PGK-1联合DCE-MRI参数在前列腺癌中的临床应用价值  

Clinical application value of serum Golgi glycoprotein 73 and phosphoglycerate kinase 1 combined with dynamic enhanced magnetic resonance scanning parameters in prostate cancer

作　　者：安宁 何宏艳 程佳琪 程晓露 赵增喜[1] AN Ning;HE Hongyan;CHENG Jiaqi;CHENG Xiaolu;ZHAO Zengxi(Department of Urology Surgery,The Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China)

机构地区：[1]河北北方学院附属第二医院泌尿外科,河北张家口075100

出　　处：《临床肿瘤学杂志》2024年第7期681-685,共5页Chinese Clinical Oncology

基　　金：河北省卫生健康委员会2023年基金项目(20231468)。

摘　　要：目的探讨血清高尔基体糖蛋白73(GP73)、磷酸甘油酸激酶1(PGK-1)联合磁共振动态增强扫描(DCE-MRI)参数与前列腺癌病理特征的关联性及预后评估价值。方法选取2018年3月至2022年3月收治的前列腺癌患者78例纳入研究组,另选50例良性前列腺增生患者纳入对照组,比较两组的血清GP73、PGK-1水平及DCE-MRI参数[容积转运常数(Ktrans)、速率常数(Kep)和血管外细胞外容积分数(Ve)],并探究其对前列腺癌的诊断及预后预测价值。结果与对照组相比较,治疗前研究组的GP73、PGK-1、Kep、Ktrans水平均升高(P<0.05)。受试者工作特征(ROC)曲线分析显示治疗前GP73、PGK-1、Kep、Ktrans分别及联合诊断前列腺癌的价值较高,其曲线下面积(AUC)值分别为0.846、0.865、0.725、0.819,联合诊断的AUC值为0.945。治疗后研究组的GP73、PGK-1、Kep水平均低于治疗前,而Ktrans、Ve水平均高于治疗前(P<0.05)。预后不良组治疗后的GP73、PGK-1、Kep、Ktrans、Ve水平均高于预后良好组(P<0.05)。ROC曲线分析显示治疗后GP73、PGK-1、Kep、Ktrans、Ve水平分别及联合预测前列腺癌患者预后不良的价值较高,其AUC值分别为0.797、0.766、0.772、0.729、0.733,联合预测的AUC值为0.967。结论血清GP73、PGK-1水平及DCE-MRI参数(Kep、Ktrans、Ve)在前列腺癌患者及预后不良者中升高,能辅助诊断患者前列腺癌的发生,并对患者预后不良情况进行及早预测。Objective To explore the correlation of serum Golgi glycoprotein 73(GP73),phosphoglycerate kinase 1(PGK-1)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters with pathological features and prognostic value of prostate cancer.Methods Seventy-eight patients with prostate cancer treated in our hospital from March 2018 to March 2022 were selected to be included in the study group,and 50 patients with benign prostatic hyperplasia treated in our hospital were selected to be included in the control group.The DCE-MRI parameters including volume transfer coefficient(Ktrans),reverse reflux rate constant(Kep),extracellular extravascular volume fraction(Ve)and serum GP73 and PGK-1 levels of the two groups were compared.The diagnostic and prognostic value for prostate cancer of the above indices were investigated.Results Compared with the control group,levels of GP73,PGK-1,Kep,and Ktrans in the study group increased before treatment(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that GP73,PGK-1,Kep,Ktrans,and their combination had high diagnostic value for prostate cancer before treatment.The area under the curve(AUC)values were 0.846,0.865,0.725,and 0.819,respectively,and the AUC value for combined diagnosis was 0.945.After treatment,the levels of GP73,PGK-1,and Kep in the study group were lower than those before treatment,while the levels of Ktrans and Ve were higher than those before treatment(P<0.05).Levels of GP73,PGK-1,Kep,Ktrans,and Ve in the group with poor prognosis after treatment were higher than those in the group with good prognosis(P<0.05).ROC curve analysis showed that the levels of GP73,PGK-1,Kep,Ktrans,and Ve as well as their combination had high predictive value for poor prognosis in prostate cancer patients after treatment,with AUC values of 0.797,0.766,0.772,0.729,0.733 and 0.967.Conclusion Serum GP73,PGK-1 levels and DCE-MRI parameters(Kep,Ktrans,Ve values)are significantly increased in prostate cancer patients and patients with poor prognosis,which can assist

关 键 词：前列腺癌 高尔基体糖蛋白73 磷酸甘油酸激酶1 磁共振动态增强扫描 预后 诊断价值 

分 类 号：R737.25[医药卫生—肿瘤]