血清sICAM-1、CHI3L1、TSGF、KL-6联合检测在胰腺癌早期临床诊断中的价值  

Value of combined detection of serum sICAM-1,CHI3L1,TSGF and KL-6 in the early clinical diagnosis of pancreatic cancer

作　　者：宋洁 刘翔 吕锦春 刘世光 SONG Jie;LIU Xiang;LYU Jinchun;LIU Shiguang(Department of Laboratory Medicine,Qionglai Hospital of Traditional Chinese Medicine,Qionglai 611530,China)

机构地区：[1]邛崃市中医医院检验科,四川邛崃611530 [2]邛崃市中医医院肿瘤科,611530

出　　处：《临床肿瘤学杂志》2024年第7期690-694,共5页Chinese Clinical Oncology

摘　　要：目的探讨血清可溶性细胞间黏附分子-1(sICAM-1)、壳多糖酶3样蛋白1(CHI3L1)、肿瘤特异生长因子(TSGF)、涎液化糖链抗原(KL-6)联合检测在胰腺癌早期临床诊治中的价值。方法选择2021年7月至2023年7月收治的52例Ⅰ期胰腺癌患者为胰腺癌组,另选择50例同期体检健康志愿者为对照组,比较两组受检者的血清sICAM-1、CHI3L1、TSGF、KL-6和糖类抗原19-9(CA19-9)水平,Pearson相关分析血清sICAM-1、CHI3L1、TSGF、KL-6与血清CA19-9相关性,并借助受试者工作特征(ROC)曲线分析以上指标联合检测对Ⅰ期胰腺癌的临床诊断价值。结果胰腺癌组的血清sICAM-1、CHI3L1、TSGF、KL-6和CA19-9水平均高于对照组(t=6.825、8.359、7.553、6.814、11.532,P<0.05)。Pearson相关分析显示,血清sICAM-1、CHI3L1、TSGF、KL-6均与CA19-9呈正相关(r=0.647、0.746、0.697、0.693,P<0.05)。ROC曲线显示,sICAM-1、CHI3L1、TSGF、KL-6和CA19-9对Ⅰ期胰腺癌具有一定临床辅助诊断价值(AUC=0.812、0.888、0.850、0.827、0.958,P<0.05),且联合检测(AUC=0.970,P<0.05)的临床辅助诊断价值较高。结论血清sICAM-1、CHI3L1、TSGF、KL-6和CA19-9联合检测对早期胰腺癌具有较高的临床辅助诊断价值。Objective To investigate the clinical value of serum soluble intercellular adhesion molecule 1(sICAM-1),chitosinase 3-like protein 1(CHI3L1),tumor specific growth factor(TSGF)and salivary glycosylated antigen(KL-6)in the early clinical diagnosis of pancreatic cancer.Methods Fifty-two patients with stage I pancreatic cancer admitted from July 2021 to July 2023 were selected as the pancreatic cancer group,and 50 healthy volunteers who underwent physical examination during the same period were selected as the control group.Serum levels of sICAM-1,CHI3L1,TSGF,KL-6 and carbohydrate antigen 19-9(CA19-9)were compared between the two groups.Pearson correlation was used to analyze the correlation between serum sICAM-1,CHI3L1,TSGF,KL-6 and serum CA19-9,and the value of the combined detection of these indicators in the clinical diagnosis of stage I pancreatic cancer was analyzed by receiver operating characteristic(ROC)curve.Results The serum levels of sICAM-1,CHI3L1,TSGF,KL-6 and CA19-9 in pancreatic cancer group were higher than those in control group(t=6.825,8.359,7.553,6.814,11.532,P<0.05).Pearson correlation analysis showed that serum sICAM-1,CHI3L1,TSGF and KL-6 were significantly positively correlated with CA19-9(r=0.647,0.746,0.697,0.693,P<0.05).ROC curve showed that sICAM-1,CHI3L1,TSGF,KL-6 and CA19-9 had certain clinical auxiliary diagnostic value in stage I pancreatic cancer(AUC=0.812,0.888,0.850,0.827,0.958,P<0.05),and the value of combined detection for clinical assistant diagnosis was higher(AUC=0.970,P<0.05).Conclusion The combined detection of serum sICAM-1,CHI3L1,TSGF,KL-6 and CA19-9 have high clinical value in the early diagnosis of pancreatic cancer.

关 键 词：胰腺癌 可溶性细胞间黏附分子-1 壳多糖酶3样蛋白1 肿瘤特异生长因子 涎液化糖链抗原 联合检测 

分 类 号：R735.9[医药卫生—肿瘤]