胃癌组织的CPXCR1水平及临床意义  

Expression and clinical significance of CPXCR1 in gastric cancer tissues

作　　者：李大鹏[1] 吴颂[2] 成伟丽 张宁[1] 孙明琪 LI Dapeng;WU Song;CHENG Weili;ZHANG Ning;SUN Mingqi(Department of Digestive Oncology,Tianjin Cancer Hospital,Qinhuangdao Hospital,Qinhuangdao 066000,China)

机构地区：[1]天津市肿瘤医院秦皇岛医院消化肿瘤科,河北秦皇岛066000 [2]秦皇岛市中医医院治未病中心,066000

出　　处：《临床肿瘤学杂志》2024年第7期702-706,共5页Chinese Clinical Oncology

摘　　要：目的探讨胃癌组织中CPX染色体候选区域1(CPXCR1)的水平及其预后价值。方法选取2019年1月至2022年12月于本院行胃癌根治术的患者95例,采用实时荧光定量PCR检测CPXCR1在95例胃癌组织及对应癌旁组织中的表达差异,分析CPXCR1水平与胃癌患者临床病理特征的关系,采用Kaplan-Meier生存曲线并基于Cox比例风险模型分析CPXCR1在胃癌患者预后预测中的价值。结果95例胃癌组织的CPXCR1水平为0.791±0.035,低于癌旁组织的1.197±0.026(t=9.217,P<0.001)。分层分析显示CPXCR1表达与胃癌患者的性别(χ^(2)=0.608,P=0.436)、年龄(χ^(2)=1.935,P=0.164)、肿瘤位置(χ^(2)=0.892,P=0.640)、Lauren分型(χ^(2)=3.064,P=0.216)、分化程度(χ^(2)=0.253,P=0.615)和T分期(χ^(2)=1.772,P=0.183)无关,而与TNM分期(χ^(2)=3.903,P=0.048)、肿瘤大小(χ^(2)=6.663,P=0.010)和淋巴结转移(χ^(2)=4.915,P=0.027)有关。单因素分析显示CPXCR1表达与胃癌患者的总生存期(OS)有关,其中高表达患者的中位OS未达,优于低表达者的37个月(HR=2.414,95%CI:1.314~4.435,P=0.005);多因素分析显示CPXCR1高表达是胃癌预后不良的危险因素(HR=2.136,95%CI:1.096~3.956,P=0.022)。结论CPXCR1在胃癌中低表达且与不良预后相关,CPXCR1是一个独立的预后风险因素,也是胃癌诊断和治疗的潜在生物标志物。Objective To explore the level of CPX chromosome candidate region 1(CPXCR1)in gastric cancer tissues and its value in evaluating the prognosis of gastric cancer patients.Methods Ninety-five patients who underwent radical gastrectomy for gastric cancer in our hospital from January 2019 to December 2022 were selected.Real-time fluorescence quantitative PCR was used to detect the differential expression of CPXCR1 in gastric cancer tissues and corresponding adjacent tissues.The relationship between CPXCR1 levels and clinical pathological characteristics of gastric cancer patients was analyzed.The Kaplan Meier survival curve and Cox proportional risk model were used to analyze the value of CPXCR1 in predicting the prognosis of gastric cancer patients.Results The level of CPXCR1 in 95 gastric cancer tissues was 0.791±0.035,which was lower than 1.197±0.026 in adjacent tissues(t=9.217,P<0.001).Layered analysis showed that the expression of CPXCR1 was not related to gender(χ^(2)=0.608,P=0.436),age(χ^(2)=1.935,P=0.164),tumor location(χ^(2)=0.892,P=0.640),Lauren classification(χ^(2)=3.064,P=0.216),differentiation degree(χ^(2)=0.253,P=0.615)and T stage(χ^(2)=1.772,P=0.183)in gastric cancer patients(P>0.05),but was related to TNM stage(χ^(2)=3.903,P=0.048),tumor size(χ^(2)=6.663,P=0.010)and lymph node metastasis(χ^(2)=4.915,P=0.027).Univariate analysis showed that the expression of CPXCR1 was associated with overall survival(OS)in gastric cancer patients,with the unreached median OS in high expression patients,which was better than 37 months in low expression patients(HR=2.414,95%CI:1.314-4.435,P=0.005).Multivariate analysis showed that low expression of CPXCR1 was a risk factor for poor prognosis in gastric cancer(HR=2.136,95%CI:1.096-3.956,P=0.022).Conclusion CPXCR1 is lowly expressed in gastric cancer and is associated with poor prognosis.CPXCR1 is an independent prognostic risk factor and a potential biomarker for the diagnosis and treatment of gastric cancer.

关 键 词：胃癌 CPX染色体候选区域1 临床意义 预后 

分 类 号：R735.2[医药卫生—肿瘤]