食管鳞状细胞癌化疗联合免疫治疗后病理消退模式分析  

The Pathological Regression Pattern of Residual Tumor in Radical Specimens of Patients with Esophageal Squamous Cell Carcinoma after Preoperative Chemotherapy Combined with Immunotherapy

作　　者：奚丽娜 李军扩[1] 孙媛媛 杨海军[1] XI Lina;LI Junkuo;SUN Yuanyuan;YANG Haijun(Anyang Tumor Hospital,Anyang,China,455000)

机构地区：[1]安阳市肿瘤医院,河南安阳455000

出　　处：《食管疾病》2024年第4期241-245,共5页Journal of Esophageal Diseases

摘　　要：目的探讨局部晚期食管鳞状细胞癌患者化疗联合免疫治疗后根治标本中残留肿瘤的病理消退模式。方法回顾性分析411例接受2~4周期化疗联合免疫治疗后行食管癌根治性切除术的标本,根据其食管壁内残存肿瘤的消退方向进行分类并分析。结果411例中有70例(17.03%)为向管腔消退,14例(3.41%)为向纤维膜消退,7例(1.70%)为同心样消退,199例(48.42%)为随机样消退,120例(29.20%)为完全消退,1例尚未归类。结论残留肿瘤消退方向以随机样消退最多,其次为完全消退,同心样消退最少。其中完全消退的病例为食管癌患者保留食管治疗策略提供了新的数据支持。Objective To explore the pathological regression pattern of residual tumor in radical specimens of patients with locally advanced esophageal squamous cell carcinoma after preoperative chemotherapy combined with immunotherapy.Methods A retrospective analysis was performed on the specimens of 411 patients who underwent radical resection of esophageal cancer after 2-4 cycles of chemotherapy combined with immunotherapy.The specimens were classified and analyzed according to the regression direction of the residual tumor in the esophageal wall.Results Among the 411cases,70 cases(17.03%)were regressed into the lumen,14 cases(3.41%)were regressed into the fibrous membrane,7 cases(1.70%)were concentric regressed,199 cases(48.42%)were random regressed,and 120 cases(29.20%)were completely regressed.One case was not yet classified.Conclusion Random regression was the most common direction of residual tumor regression,followed by complete regression,concentric regressed was the least.The cases of complete regression provide new data support for the esophageal preservation treatment strategy for patients with esophageal cancer.

关 键 词：食管鳞状细胞癌 免疫治疗 化疗 残留肿瘤 消退模式 

分 类 号：R735.1[医药卫生—肿瘤] R361.2[医药卫生—临床医学]