降钙素基因相关肽及血红素氧合酶-1对反流性食管炎病情评估及预后的价值分析  

Severity Evaluation and Prognosis Value of Calcitonin Gene-related Peptide and Heme Oxygenase-1 in Reflux Esophagitis

作　　者：李凤敏 LI Fengmin(Department of Gastroenterology,Kaifeng People′s Hospital,Kaifeng,China,475000)

机构地区：[1]开封市人民医院消化内科,河南开封475000

出　　处：《食管疾病》2024年第4期288-291,300,共5页Journal of Esophageal Diseases

摘　　要：目的分析血清降钙素基因相关肽(calcitonin gene-related peptide,CGRP)及血红素氧合酶-1(heme oxygenase-1,HO-1)的丰度在反流性食管炎(reflux esophagitis,RE)中的预后价值。方法选取开封市人民医院2022年6月至2023年5月收治的90例RE患者纳入观察组,同时选取在同期参与体检的45例健康个体纳入对照组。分析血清CGRP及HO-1丰度与GerdQ评分的相关性及其联合预后价值。结果观察组病患血清CGRP及HO-1丰度与对照组相比升高(P<0.001);血清CGRP丰度、HO-1丰度及GerdQ评分对比,中度组与轻度组相比均升高,重度组与中度组相比均升高(P<0.05)。Pearson相关性分析结果表明RE病患血清CGRP丰度以及HO-1丰度与GerdQ评分都呈现正相关(P<0.01)。血清CGRP及HO-1预测RE病患预后不良的曲线下面积(AUC)分别为0.841及0.877,二者联合将AUC提高到了0.937。结论血清CGRP联合HO-1对RE患者预后有较高的预测价值。Objective To analyze the prognostic value of serum CGRP and heme oxygenase-1(HO-1)in reflux esophagitis(RE).Methods 90 RE patients admitted to our hospital from June 2022 to May 2023 were selected as the observation group,and 45 healthy people who participated in physical examination during the same period were selected as the control group.The correlations between serum CGRP,HO-1 levels,GerdQ score,as well as their combined prognostic value were analyzed.Results The levels of serum CGRP and HO-1 in the observation group patients increased compared to the control group(P<0.001).The levels of serum CGRP,HO-1,and GerdQ score in the moderate group were higher than those in the mild group,while levels of serum CGRP,HO-1,and GerdQ score in the severe group showed an increase compared to the moderate group(P<0.05).The Pearson correlation analysis results showed that the serum CGRP level and HO-1 level of RE patients were positively correlated with GerdQ score(P<0.01).The area under the curve(AUC)of serum CGRP and HO-1 predicting poor prognosis in RE patients was 0.841 and 0.877,respectively,and the combination of the two increased the AUC to 0.937.Conclusion The combination of serum CGRP and HO-1 has a high predictive value for the prognosis of RE patients.

关 键 词：反流性食管炎 血清 CGRP HO-1 预后 

分 类 号：R571[医药卫生—消化系统]