基于网络药理学探讨蒙药豆蔻治疗失眠症的作用机制  

The Mechanism of Action of Mongolian Medicine Cardamom in Treating Insomnia Was Studied Based on Network Pharmacology

作　　者：那合雅 赵福全[2] Naheya;ZHAO Fuquan(Clinical Medical College of Inner Mongolia University for Nationalities,Tongliao 028043,China;Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao 028050,China)

机构地区：[1]内蒙古民族大学临床医学院,内蒙古通辽028043 [2]内蒙古民族大学附属医院,内蒙古通辽028050

出　　处：《中国民族医药杂志》2024年第11期34-39,共6页Journal of Medicine and Pharmacy of Chinese Minorities

摘　　要：目的:基于网络药理学研究蒙药豆蔻治疗失眠症的作用机制。方法:通过TCMSP数据库检索蒙药豆蔻的有效成分及相关靶点;通过Gene Cards、OMIM、TTD三个数据库搜索失眠症相关基因靶点;利用Venny 2.1.0获得疾病与药物交集靶点,再通过PPI网络分析、GO富集及KEGG富集分析,并对获得的结果进行可视化分析。结果:(1)获得12种活性成分,治疗靶点122个。主要活性成分有槲皮素和木犀草素;(2)蛋白互作网络中的核心靶点有AKT1、TNF、TP53、IL6、IL1B;(3)GO富集分析BP主要细胞对脂质的反应、对外来刺激的反应、对激素的反应等;CC主要存在于膜筏、转录调控复合体、质膜蛋白复合物等;MF主要富集在DNA结合转录因子结合、蛋白质结构域特异性结合、细胞因子受体结合等;途径有癌症的途径、脂质和动脉粥样硬化、流体剪切应力与动脉粥样硬化等通路;(4)蒙药豆蔻可能通过调节机体炎症介质和神经递质来发挥作用。结论:本文运用网络药理学,对蒙药豆蔻治疗失眠症的作用机制进行了初步探讨,为更深一步研究该药或含有该药的方剂提供了药效物质基础和作用靶点理论依据。Objective:To study the mechanism of action of Mongolian medicine cardamom in the treatment of insomnia based on network pharmacology.Methods:The active constituents and related targets of Mongolian medicine Cardamom were searched by TCMSP database.Insomnia-related Gene targets were searched through Gene Cards,OMIM and TTD databases.Venny 2.1.0 was used to obtain the intersection target of disease and drug,and then PPI network analysis,GO enrichment and KEGG enrichment analysis were performed,and the obtained results were visually analyzed.Results:(1)12 active ingredients and 122 therapeutic targets were obtained.The main active ingredients are quercetin and luteolin.(2)The core targets in the protein interaction network were AKT1,TNF,TP53,IL6 and IL1B.(3)GO enrichment was used to analyze the reaction of BP cells to lipids,to foreign stimuli,to hormones,etc.CC mainly exists in membrane rafts,transcriptional regulatory complexes,plasma membrane protein complexes,etc.MF is mainly concentrated in DNA binding,transcription factor binding,protein domain specific binding,cytokine receptor binding,etc.The pathways include cancer pathway,lipid and atherosclerosis pathway,fluid shear stress and atherosclerosis pathway,etc.(4)The Mongolian medicine cardamom may play a role by regulating inflammatory mediators and neurotransmitters in the body.Conclusion:In this paper,the mechanism of action of Mongolian medicine cardamom in the treatment of insomnia was preliminarily discussed by means of network pharmacology,which provided a theoretical basis for further study of the drug or the prescription containing the drug.

关 键 词：蒙药豆蔻 网络药理学 失眠症 作用机制 

分 类 号：R749.71[医药卫生—神经病学与精神病学]