基于数据挖掘技术探讨宣桂琪教授治疗小儿多动症的用药规律  

Exploring the medication patterns of professor XUAN Guiqi in treating childhood attention deficit hyperactivity disorder based on data mining technology

作　　者：胡珏 俞珂频 许佳烨 王博涵 宣晓波[2] 陈健 宣桂琪(指导) HU Jue;YU Kepin;XU Jiaye;WANG Bohan;XUAN Xiaobo;CHEN Jian;XUAN Guiqi(The First School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang,310053,China;The Pediatrics Department,Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang,310006,China;不详)

机构地区：[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]浙江省中医院儿科,浙江杭州310006 [3]不详

出　　处：《中医儿科杂志》2024年第6期27-32,共6页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：杭州宣氏儿科流派传承工作室建设项目(国家中医药管理局人教函[2012]228号);宣桂琪名老中医药专家传承工作室建设项目(GZS2021004)。

摘　　要：目的基于中医传承计算平台(TCMICS V3.0)挖掘宣桂琪教授治疗小儿多动症(ADHD)的临床用药规律。方法收集2018—2022年宣教授治疗小儿ADHD的临床病案,借助TCMICS V3.0对标准化数据进行录入,挖掘相关用药规律。结果共收集患儿88例,发现高频症状20个;共计227个临床病案,中药合计115味,使用频数≥17次的中药有32味,前10味为远志、益智仁、龟甲、白芍、龙齿、磁石、石菖蒲、郁金、茯神、黄精,以补虚类、安神类、收涩类药为主;药性以寒性居多,其次是温、平性;药味以苦、甘、辛味为主;归经多属肾、肝、心经;关联、聚类分析中,高频药物多以“孔圣枕中丹”为基本方化裁加减。结论宣教授认为小儿ADHD的主要病机为肾气不足导致肝阳上亢、脑失所养,虚、火、痰、食是重要病理因素,治疗多从肾论治,兼顾肝、心,强调家庭宣教及饮食调护。治法以益肾潜阳、滋阴开窍为主,宁心安神为辅,同时佐以消食、化痰、清热、祛瘀等,寒温并用,动静结合,应用灵活,配伍严谨,达到阴阳平调的目的。Objective To mine the clinical medication patterns of professor XUAN Guiqi in treating childhood attention deficit hyperactivity disorder(ADHD)based on the Traditional Chinese Medicine Inheritance Calculation Platform(TCMICS V3.0).Methods Clinical case records of ADHD patients treated by professor XUAN from 2018 to 2022 were collected,and standardized data were entered into TCMICS V3.0 for data mining to identify medication patterns.Results A total of 88 ADHD patients treated by professor XUAN were included,revealing 20 high-frequency symptoms.Across 227 clinical cases,115 Chinese medicinal herbs were used,with 32 herbs having a frequency of use≥17 times.The top 10 herbs were Polygala tenuifolia Willd.,Alpinia oxyphylla Miq.,Plastrum testudinis,Radix Paeoniae Alba,Apatite,Magnetitum,Acorus tatarinowii Schott,Curcuma aromatica,Poria cum Radix Pini,and Polygonatum kingianum Coll.et Hemsl.These herbs primarily belonged to the categories of tonifying deficiency,calming the mind,and astringency.Most herbs were cold in nature,followed by warm and neutral;tastes were predominantly bitter,sweet,and pungent;and the meridian tropisms were primarily associated with the kidney,liver,and heart meridians.In correlation and cluster analysis,high-frequency herbs were often modified based on the formula of Kongsheng Zhenzhong Dan(孔圣枕中丹).Conclusion Professor XUAN believes that the primary pathogenesis of childhood ADHD is insufficient kidney qi leading to hyperactivity of liver yang and malnutrition of the brain.Deficiency,fire,phlegm,and improper diet are important pathological factors.Treatment primarily focuses on nourishing the kidney,with attention also given to the liver and heart.Emphasis is placed on family education and dietary regulation.The therapeutic approach is primarily aimed at nourishing the kidney and suppressing yang hyperactivity,nourishing yin and opening orifices,supplemented by calming the mind.Additionally,digestion-promoting,phlegm-resolving,heat-clearing,and blood-stasis-removing herbs are use

关 键 词：小儿多动症 宣氏儿科 数据挖掘 中医传承计算平台 宣桂琪 

分 类 号：R749.94[医药卫生—神经病学与精神病学]