健脾益气膏治疗小儿抽动障碍脾虚痰聚证35例临床观察  

Clinical observation on Jianpi Yiqi Gao(健脾益气膏)in the treatment of 35 cases of tic disorders with spleen deficiency and phlegm accumulation pattern in children

作　　者：朱霞 涂一世 陈丁丁 叶盼 唐其民 ZHU Xia;TU Yishi;CHEN Dingding;YE Pan;TANG Qimin(Pediatric Department,Jingzhou Traditional Chinese Medicine Hospital,Jingzhou,Hubei,434000,China)

机构地区：[1]荆州市中医医院儿科,湖北荆州434000

出　　处：《中医儿科杂志》2024年第6期71-74,共4页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：湖北省中医药管理局2023—2024年度中医药科研面上项目(ZY2023M050)。

摘　　要：目的观察健脾益气膏治疗小儿抽动障碍(TD)脾虚痰聚证的临床疗效。方法选取2021年12月至2022年12月荆州市中医医院儿科门诊就诊的TD脾虚痰聚证患儿72例,治疗期间共脱落2例(1例因不能坚持整个试验过程脱落,1例因中途自行加药剔除),采用随机数字表法分为治疗组和对照组,各35例。所有患儿均给予心理疏导作为基本治疗,对照组在基本治疗的基础上予菖麻熄风片口服,治疗组在基本治疗的基础上予健脾益气膏口服。2组均连续治疗8周后统计临床总有效率,比较治疗前后耶鲁综合抽动严重程度量表(YGTSS)总评分、中医症状总积分以及不良反应发生情况。结果治疗组的总有效率为91.43%(32/35),显著高于对照组的80.00%(28/35),2组比较,差异有统计学意义(P<0.05)。治疗前2组YGTSS总评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组YGTSS总评分均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。治疗前2组中医症状总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组中医症状总积分均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。结论健脾益气膏治疗小儿TD脾虚痰聚证疗效显著,可显著降低YGTSS总评分和中医症状总积分,值得临床推广应用。Objective To observe the clinical efficacy of Jianpi Yiqi Gao(健脾益气膏)in the treatment of tic disorders with spleen deficiency and phlegm accumulation pattern in children.Methods A total of 72 pediatric patients with tic disorders(TD)with spleen deficiency and phlegm accumulation pattern who visited the pediatric outpatient clinic of Jingzhou Traditional Chinese Medicine Hospital from December 2021 to December 2022 were selected.During the treatment period,2 patients dropped out(1 due to inability to complete the entire trial process and 1 due to self-administered additional medication),and the remaining patients were randomly divided into a treatment group and a control group,with 35 patients in each.All children received psychological counseling as basic treatment.The control group received Changma Xifeng Tablets(菖麻熄风片)orally on the basis of basic treatment,while the treatment group received Jianpi Yiqi Gao orally on the basis of basic treatment.After 8 weeks of continuous treatment,the total clinical effective rate was calculated for both groups,and comparisons were made in terms of the total Yale Global Tic Severity Scale(YGTSS)score,total traditional Chinese medicine(TCM)symptom score before and after treatment,and the occurrence of adverse reactions.Results The total effective rate in the treatment group was 91.43%(32/35),significantly higher than the 80.00%(28/35)in the control group,with a statistically significant difference between the two groups(P<0.05).There was no statistically significant difference in the total YGTSS scores between the two groups before treatment(P>0.05),indicating comparability.After treatment,the total YGTSS scores in both groups decreased significantly compared with those before treatment(P<0.05),with a more significant decrease in the treatment group(P<0.05).There was no statistically significant difference in the total TCM symptom scores between the two groups before treatment(P>0.05),indicating comparability.After treatment,the total TCM symptom scores in bo

关 键 词：抽动障碍 小儿 脾虚痰聚证 健脾益气膏 临床观察 

分 类 号：R749.94[医药卫生—神经病学与精神病学]