Biomaterials for immunomodulation in wound healing  

作　　者：Ying Wang Katrina Vizely Chen Yu Li Karen Shen Amid Shakeri Ramak Khosravi James Ryan Smith Eugene Alfonzo II Alteza Yimu Zhao Milica Radisic 

机构地区：[1]Institute of Biomedical Engineering,University of Toronto,Toronto,ON M5S 3G9,Canada [2]Toronto General Research Institute,University Health Network,Toronto,ON M5G 2C4 Canada [3]Department of Chemical Engineering and Applied Chemistry,University of Toronto,Toronto,ON M5S 3E5,Canada [4]Division of Cardiovascular and Thoracic Surgery,Department of Surgery,Duke University Medical Center,Durham,NC 27710,USA [5]Terrence Donnelly Centre for Cellular&Biomolecular Research,University of Toronto,Toronto,ON M5S 3E1,Canada

出　　处：《Regenerative Biomaterials》2024年第5期1-22,共22页再生生物材料（英文版）

基　　金：the Canadian Institutes of Health Research(CIHR)Foundation Grant FDN-167274;Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant(RGPIN 326982-10);Stem Cell Network Impact Award 920530 and National Institutes of Health Grant 2R01 HL076485.

摘　　要：The substantial economic impact of non-healing wounds,scarring,and burns stemming from skin injuries is evident,resulting in a financial burden on both patients and the healthcare system.This review paper provides an overview of the skin’s vital role in guarding against various environmental challenges as the body’s largest protective organ and associated developments in biomaterials for wound healing.We first introduce the composition of skin tissue and the intricate processes of wound healing,with special attention to the crucial role of immunomodulation in both acute and chronic wounds.This highlights how the imbalance in the immune response,particularly in chronic wounds associated with underlying health conditions such as diabetes and immunosuppression,hinders normal healing stages.Then,this review distinguishes between traditional wound-healing strategies that create an optimal microenvironment and recent peptide-based biomaterials that modulate cellular processes and immune responses to facilitate wound closure.Additionally,we highlight the importance of considering the stages of wounds in the healing process.By integrating advanced materials engineering with an in-depth understanding of wound biology,this approach holds promise for reshaping the field of wound management and ultimately offering improved outcomes for patients with acute and chronic wounds.

关 键 词：IMMUNOMODULATION peptide-based biomaterials innate immunity angiogenesis for wound healing cellular response 

分 类 号：R318[医药卫生—生物医学工程]