In vitro and in vivo degradation,biocompatibility and bone repair performance of strontium-doped montmorillonite coating on Mg-Ca alloy  

作　　者：Wenxin Sun Kaining Yang Yuhong Zou Yande Ren Lin Zhang Fen Zhang Rongchang Zeng 

机构地区：[1]Department of Bioengineering,College of Chemical and Biological Engineering,Shandong University of Science and Technology,Qingdao 266590,China [2]Affiliated Hospital of Medical College Qingdao University,Qingdao 266555,China [3]Hospital of Shandong,University of Science and Technology,Qingdao 266590,China [4]Corrosion Laboratory for Light Metals,College of Materials Science and Engineering,Shandong University of Science and Technology,Qingdao 266590,China

出　　处：《Regenerative Biomaterials》2024年第5期74-89,共16页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant number 52071191);the Shandong Provincial Natural Science Foundation of China(grant number ZR 2020ME011).

摘　　要：Poor bone growth remains a challenge for degradable bone implants.Montmorillonite and strontium were selected as the carrier and bone growth promoting elements to prepare strontium-doped montmorillonite coating on Mg-Ca alloy.The surface morphology and composition were characterized by SEM,EDS,XPS,FT-IR and XRD.The hydrogen evolution experiment and electrochemical test results showed that the Mg-Ca alloy coated with Sr-MMT coating possessed optimal corrosion resistance performance.Furthermore,in vitro studies on cell activity,ALP activity,and cell morphology confirmed that Sr-MMT coating had satisfactory biocompatibility,which can significantly avail the proliferation,differentiation,and adhesion of osteoblasts.Moreover,the results of the 90-day implantation experiment in rats indicated that,the preparation of Sr-MMT coating effectively advanced the biocompatibility and bone repair performance of Mg-Ca alloy.In addition,The Osteogenic ability of Sr-MMT coating may be due to the combined effect of the precipitation of Si4+and Sr^(2+)in Sr-MMT coating and the dissolution of Mg^(2+)and Ca^(2+)during the degradation of Mg-Ca alloy.By using coating technology,this study provides a late-model strategy for biodegradable Mg alloys with good corrosion resistance,biocompatibility.This new material will bring more possibilities in bone repair.

关 键 词：Mg-Ca alloy MONTMORILLONITE STRONTIUM corrosion resistance BIOCOMPATIBILITY OSTEOGENESIS 

分 类 号：TG146[一般工业技术—材料科学与工程]