玻璃体腔注射康柏西普辅助全视网膜激光光凝术治疗增殖期糖尿病视网膜病变伴黄斑水肿的效果及安全性  

Effect and safety of intravitreal injection of conbercept assisted panretinal laser photocoagulation on proliferative diabetic retinopathy with macular edema

作　　者：韩文涛 闫梅 Han Wentao;Yan Mei(Surgery of Fundus Diseases I,the First People’s Hospital of Xianyang,Xianyang 712000,China;Department of Ophthalmology,the First People’s Hospital of Xianyang,Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院眼底病外一科,咸阳712000 [2]咸阳市第一人民医院眼底病内科,咸阳712000

出　　处：《中国实用医刊》2024年第21期49-52,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析玻璃体腔注射康柏西普辅助全视网膜激光光凝术(PRP)治疗增殖期糖尿病视网膜病变(PDR)伴黄斑水肿的效果和安全性。方法回顾性抽取2021年9月至2023年9月咸阳市第一人民医院收治的PDR伴黄斑水肿患者92例,按照治疗措施将其分为对照组(46例,给予单纯PRP治疗)和观察组(46例,给予玻璃体腔注射康柏西普+PRP治疗)。比较两组治疗效果、视网膜血流动力学、最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)、并发症发生率、黄斑水肿加重情况。结果观察组治疗总有效率(93.48%,43/46)高于对照组(78.26%,36/46),并发症发生率(4.35%,2/46)低于对照组(17.39%,8/46),P<0.05。治疗后,观察组视网膜浅层毛细血管密度为(53.69±5.21)%,视网膜深层毛细血管密度为(37.95±4.15)%,BCVA为0.59±0.14,均高于对照组的(50.57±4.01)%、(35.11±3.63)%、0.45±0.09,P均<0.05;观察组CMT为(226.87±16.45)μm,低于对照组的(287.53±20.36)μm,P<0.05。两组黄斑水肿加重情况比较差异未见统计学意义(P>0.05)。结论玻璃体腔注射康柏西普辅助PRP可调节PDR伴黄斑水肿患者的视网膜血流动力学,提高视力,降低CMT,且并发症较少。ObjectiveTo analyze the effect and safety of intravitreal injection of conbercept assisted panretinal laser photocoagulation(PRP)for proliferative diabetic retinopathy(PDR)with macular edema.MethodsA total of 92 patients with PDR complicated by macular edema admitted to the First People’s Hospital of Xianyang from September 2021 to September 2023 were retrospectively selected,and they were divided into control group(46 cases,given PRP treatment alone)and observation group(46 cases,treated with intravitreal conbercept combined with PRP).The treatment effect,retinal hemodynamics,best corrected visual acuity(BCVA),central macular thickness(CMT),incidences of complications and aggravation of macular edema were compared between the two groups.ResultsThe total effective rate of treatment in the observation group(93.48%,43/46)was higher than that in the control group(78.26%,36/46),and the incidence of complications in the observation group(4.35%,2/46)was lower than that in the control group(17.39%,8/46),all P<0.05.After treatment,the superficial retinal capillary density in the observation group was(53.69±5.21)%,the deep retinal capillary density was(37.95±4.15)%,and the BCVA was 0.59±0.14;the above indexes in the observation group were higher than the(50.57±4.01)%,(35.11±3.63)%,and 0.45±0.09 in the control group,respectively,all P<0.05.The CMT in the observation group was(226.87±16.45)μm,which was lower than the(287.53±20.36)μm in the control group(P<0.05).There was no significant difference in the incidence of aggravation of macular edema between the two groups(P>0.05).ConclusionsIntravitreous injection of conbercept assisted PRP can regulate retinal hemodynamics,improve vision,and reduce CMT in patients with PDR complicated by macular edema,with fewer complications.

关 键 词：增殖期糖尿病视网膜病变 黄斑水肿 康柏西普 全视网膜激光光凝术 

分 类 号：R779.63[医药卫生—眼科] R587.2[医药卫生—临床医学]