特纳综合征生育力评估及生育力保护的研究进展  

Research advances in fertility assessment and fertility protection inTurner syndrome

作　　者：刘晓景 卫海燕[1] LIU Xiao-jing;WEI Haiyan(Zhengzhou University Affiliated Children's Hospital,Endocrinology,Genetics and Metabolism Department,Henan Children's Hospital,Zhengzhou 450018,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院内分泌遗传代谢科,河南郑州450018

出　　处：《中国实用儿科杂志》2024年第11期815-819,共5页Chinese Journal of Practical Pediatrics

基　　金：河南省科学技术厅项目(232102310088);郑州市科技惠民计划项目(2022KJHM005)。

摘　　要：女性生育力即卵巢储备功能,生育力保护是指对可能引起女性生育力受损的因素采取早期筛查、治疗及特殊的生育力保存措施,以达到产生遗传学后代的能力。早发性卵巢发育不全是特纳综合征(Turner syndrome)的主要临床特征,约98%的患儿卵巢储备功能在成年前出现衰竭、生育力丧失,仅有2%的患儿成年后能够自然受孕。在儿童期及青春期早期,部分患儿的卵巢储备功能尚存在。该文重点阐述如何在早期对特纳综合征患儿进行卵巢功能评估,并在合适的时机启动卵巢功能保护措施。Female fertility refers to ovarian reserve function.Fertility protection refers to the early screening,treatment and special fertility preservation measures for factors that may cause impaired female fertility,so as to achieve the ability to produce genetic offspring.Premature ovarian hypoplasia is the main clinical feature of Turner syndrome,and about 98%of patients have ovarian reserve failure and fertility loss before adulthood,so only about 2%of patients are able to conceive naturally in adulthood.In childhood and early adolescence,ovarian reserve is still present in some children.This article focuses on how to evaluate the ovarian function of children with Turner syndrome at an early stage,and how to start the protective measures for ovarian function at the right time.

关 键 词：特纳综合征 先天性卵巢发育不全 生育力评估 生育力保护 

分 类 号：R72[医药卫生—儿科]