男性先天性低促性腺激素性性腺功能减退症的全生命周期管理  

Comprehensive life-cycle management of male congenital hypogonadotropic hypogonadism

作　　者：苏尉 苏喆[1] SU Wei;SU Zhe(Shenzhen Children's Hospital,Shenzhen 518038,China)

机构地区：[1]深圳市儿童医院,广东深圳518038

出　　处：《中国实用儿科杂志》2024年第11期820-825,共6页Chinese Journal of Practical Pediatrics

基　　金：广东省卫生健康委员会高水平临床重点专科项目(SZGSP012);深圳市科技计划资助可持续发展项目(KCXFZ20201221173400002)。

摘　　要：先天性低促性腺激素性性腺功能减退症(congenital hypogonadotropic hypogonadism,CHH)是以小阴茎、隐睾、第二性征部分发育或不发育等为主要表现,发病机制复杂、临床表现异质性大的一种疾病,不同生命阶段或不同临床表型的治疗侧重和方案有所差异,及时诊断、合理治疗有利于性发育、骨骼和代谢健康,并可能有助于减少CHH的心理影响。Congenital hypogonadotropic hypogonadism(CHH)is primarily characterized by manifestations such as micropenis,cryptorchidism,and partial or complete lack of development of secondary sexual characteristics.The disease has a complex pathogenesis and exhibits a wide range of clinical phenotypes.Treatment focus and protocols vary across different stages of life and clinical phenotypes.Timely diagnosis and appropriate treatment are beneficial to sexual development,bone and metabolic health,and may also help to mitigate some of the psychological impacts of CHH.

关 键 词：先天性低促性腺激素性性腺发育不良 下丘脑-垂体-性腺轴 脉冲式促性腺激素释放激素治疗 重组人促卵泡激素 

分 类 号：R72[医药卫生—儿科]