Immunocyte membrane-derived biomimetic nano-drug delivery system:a pioneering platform for tumour immunotherapy  

作　　者：Yuan-ye Zeng Qing Gu Dan Li Ai-xue Li Rong-mei Liu Jian-ying Liang Ji-yong Liu 

机构地区：[1]School of Pharmacy,Fudan University,Shanghai 201203,China [2]Department of Pharmacy,Fudan University Shanghai Cancer Center,Shanghai 200032,China [3]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China [4]Department of Pharmacy,Jingan District Zhabei Central Hospital,Shanghai 200070,China

出　　处：《Acta Pharmacologica Sinica》2024年第12期2455-2473,共19页中国药理学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82274103,82074272,China);the Young Scientists Fund of the National Natural Science Foundation of China(82305039,China);Program of Shanghai Academic Research Leader(21XD1403400,China);Program of National Key Research and Development(2023YFC3404103,China);the Cooperation Program of the Xuhui District Medical College with Enterprisess(23XHYD-24,China);the Science and Technology Commission of Shanghai Municipality(23S21900200,China)。

摘　　要：Tumor immunotherapy characterized by its high specificity and minimal side effects has achieved revolutionary progress in the field of cancer treatment.However,the complex mechanisms of tumor immune microenvironment(TIME)and the individual variability of patients’immune system still present significant challenges to its clinical application.Immunocyte membrane-coated nanocarrier systems,as an innovative biomimetic drug delivery platform,exhibit remarkable advantages in tumor immunotherapy due to their high targeting capability,good biocompatibility and low immunogenicity.In this review we summarize the latest research advances in biomimetic delivery systems based on immune cells for tumor immunotherapy.We outline the existing methods of tumor immunotherapy including immune checkpoint therapy,adoptive cell transfer therapy and cancer vaccines etc.with a focus on the application of various immunocyte membranes in tumor immunotherapy and their prospects and challenges in drug delivery and immune modulation.We look forward to further exploring the application of biomimetic delivery systems based on immunocyte membrane-coated nanoparticles,aiming to provide a new framework for the clinical treatment of tumor immunity.

关 键 词：tumour immunotherapy biomimetic nanoparticles immunocyte membrane drug delivery 

分 类 号：R730.51[医药卫生—肿瘤]