BAP1蛋白表达缺失对恶性间皮瘤患者的预后价值研究  

The prognostic value of BAP1 protein loss in patients with malignant mesothelioma

作　　者：陈祎秋 高志斌[2] 沈蔚 应士波 何向蕾[4] 张幸 蒋兆强 楼建林 Chen Yiqiu;Gao Zhibin;Shen Wei;Ying Shibo;He Xianglei;Zhang Xing;Jiang Zhaoqiang;Lou Jianlin(School of Public Health,Hangzhou Medical College,Hangzhou 310000,China;Department of Pathology,Yuyao People's Hospital,Ningbo 315000,China;Department of Respiratory Medicine,The Third People's Hospital of Cixi,Ningbo 315000,China;Department of Pathology,Zhejiang Provincial People's Hospital,Hangzhou 310000,China;School of Medicine,and The First Affiliated Hospital,Huzhou University,Huzhou 313000,China)

机构地区：[1]杭州医学院公共卫生学院,杭州310000 [2]余姚市人民医院病理科,宁波315000 [3]慈溪第三人民医院呼吸内科,宁波315000 [4]浙江省人民医院病理科,杭州310000 [5]湖州师范学院医学院,湖州师范学院附属第一医院,湖州313000

出　　处：《中华劳动卫生职业病杂志》2024年第11期815-820,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：杭州医学院基础科研计划(KYYB202113);国家自然科学基金(81973011);浙江省一流学科(A类)公共卫生与预防医学。

摘　　要：目的探索BRCA1相关蛋白1(BRCA1-associated protein 1,BAP1)表达缺失对恶性间皮瘤(malignant mesothelioma,MM)患者的预后价值。方法选取浙江省1998年1月至2017年12月收治的82例MM患者,通过免疫组织化学分析检测BAP1蛋白的表达。用Kaplan-Meier法绘制生存曲线,用多变量Cox比例风险模型分析生存率的影响因素。结果82例MM患者中女性61例(74.4%),年龄(57±11)岁。39例(47.6%)患者存在BAP1蛋白表达缺失。患者生存率与BAP1蛋白表达缺失及其年龄相关(χ^(2)=5.27、5.66,P=0.022、0.017)。亚组分析显示,BAP1蛋白表达缺失与年龄<57岁、女性、胸膜MM、上皮型MM、采用药物或手术治疗方法的MM患者预后较好相关(P<0.05)。多变量模型结果显示,BAP1蛋白阳性表达(HR=3.75,95%CI:2.23~6.30,P<0.001)以及年龄≥57岁(HR=1.66,95%CI:1.01~2.72,P=0.049)是MM患者生存的危险因素。结论BAP1蛋白表达缺失可能是MM患者的独立预后因素,与患者较长的生存率相关。ObjectiveTo explore the prognostic value of BRCA1-associated protein 1(BAP1)expression loss in patients with malignant mesothelioma(MM).MethodsA total of 82 MM patients from January 1998 to December 2017 in Zhejiang Province were selected to detect the expression of BAP1 protein by immunohistochemical analysis.Kaplan-Meier method was used to draw the survival curve,and multivariate Cox proportional risk model was used to analyze the factors affecting the survival rate.ResultsAmong 82 MM patients,61(74.4%)were female,aged(57±11)years.BAP1 protein expression was deficient in 39 patients(47.6%).The survival rate was correlated with the loss of BAP1 protein expression and age(χ^(2)=5.27,5.66,P=0.022,0.017).Subgroup analysis showed that loss of BAP1 protein expression was associated with better prognosis in MM patients<57 years of age,female,pleural MM,epithelial MM,and treated with drugs or surgery(P<0.05).Multivariate model results showed that positive expression of BAP1 protein(HR=3.75,95%CI:2.23-6.30,P<0.001)and age≥57 years(HR=1.66,95%CI:1.01-2.72,P=0.049)were risk factors for survival in patients with MM.ConclusionLoss of BAP1 protein expression may be an independent prognostic factor in patients with MM,which is associated with longer survival.

关 键 词：间皮瘤 恶性间皮瘤 BRCA1相关蛋白1 BAP1 石棉 预后 免疫组织化学 

分 类 号：R739.5[医药卫生—肿瘤]