鳖甲煎丸联合水飞蓟宾治疗痰瘀交阻型非酒精性脂肪性肝炎的临床效果观察  

Clinical Effect Observation of Biejiajian Pills Combined with Silibin in Treatment of Non-Alcoholic Steatohepatitis with Phlegm and Stasis Obstruction

作　　者：张勇[1] 张翠平 刘辉 周文锋 Zhang Yong;Zhang Cuiping;Liu Hui;Zhou Wenfeng(Anyang People's Hospital,Anyang 455000,Henan Province,China;Anyang Tumor Hospital,Anyang 565000,Henan Province,China)

机构地区：[1]安阳市人民医院,河南安阳455000 [2]安阳市肿瘤医院,河南安阳565000

出　　处：《中国社区医师》2024年第33期95-97,共3页Chinese Community Doctors

基　　金：安阳市2023科技发展计划项目(编号:2023CO1SF029)。

摘　　要：目的:探讨鳖甲煎丸联合水飞蓟宾治疗痰瘀交阻型非酒精性脂肪性肝炎的临床效果。方法:选取2023年1月—2024年5月安阳市人民医院收治的72例痰瘀交阻型非酒精性脂肪性肝炎患者作为研究对象,采取随机数字表法分为对照组(采用水飞蓟宾治疗)与观察组(在对照组基础上采用鳖甲煎丸治疗),各36例。对比两组治疗效果。结果:观察组治疗总有效率比对照组高(P<0.05)。治疗前,两组γ-谷氨酰转移酶(GGT)、丙氨酸氨基转移酶(ALT)、甘油三酯(TG)及天冬氨酸氨基转移酶(AST)水平对比,无统计学差异(P>0.05);治疗后,两组GGT、ALT、TG及AST水平均比治疗前低,且观察组低于对照组(P<0.05)。治疗前,两组纳差、腹胀、恶心、乏力评分对比,无统计学差异(P>0.05);治疗后,两组上述评分较治疗前低,且观察组低于对照组(P<0.05)。治疗前,两组白细胞介素-8(IL-8)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平对比,无统计学差异(P>0.05);治疗后,两组IL-8、IL-6及TNF-α水平低于治疗前,且观察组较对照组低(P<0.05)。结论:鳖甲煎丸联合水飞蓟宾治疗痰瘀交阻型非酒精性脂肪性肝炎的临床效果显著,可以改善患者肝功能,减轻其临床症状及炎性反应。Objective:To explore the clinical effect of Biejiajian Pills combined with silibin in the treatment of non-alcoholic steatohepatitis with phlegm and stasis obstruction.Methods:A total of 72 patients of non-alcoholic steatohepatitis with phlegm and stasis obstruction admitted to Anyang People's Hospital from January 2023 to May 2024 were selected as the study subjects.They were divided into a control group(treated with silibin)and an observation group(treated with Biejiajian Pills on the basis of control group)using a random number table method,with 36 cases in each group.The treatment effects were compared between two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Before treatment,there was no significant difference in the levels of gamma-glutamyl transferase(GGT),alanine transaminase(ALT),triglycerides(TG),and aspartate transaminase(AST)between the two groups(P>0.05);After treatment,the levels of GGT,ALT,TG and AST in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the scores of anorexia,abdominal distension,nausea and fatigue between the two groups(P>0.05);After treatment,the above scores in the two groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of interleukin-8(IL-8),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05);After treatment,the levels of IL-8,IL-6 and TNF-αin the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05).Conclusion:The clinical effect of Biejiajian Pills combined with silibin in the treatment of non-alcoholic steatohepatitis with phlegm and stasis obstruction is significant,which can i

关 键 词：痰瘀交阻型 非酒精性脂肪性肝炎 鳖甲煎丸 

分 类 号：R575.5[医药卫生—消化系统]