复发性阿弗他口腔溃疡的病因及治疗研究进展  

Research progress on the etiology and treatment of recurrent aphthous ulcer

作　　者：吴海潮 黎宗杰 刘懿卿 谭朝文 唐嘉杰 毛峻武 WU Haichao;LI Zongjie;LIU Yiqing;TAN Chaowen;TANG Jiajie;MAO Junwu(School of Stomatology,Guilin Medical University,Guangxi Zhuang Autonomous Region,Guilin541199,China;Department of Orthodontics,Affiliated Stomatology Hospital of Guilin Medical University,Guangxi Zhuang Autonomous Region,Guilin541004,China)

机构地区：[1]桂林医学院口腔医学院,广西桂林541199 [2]桂林医学院附属口腔医院正畸科,广西桂林541004

出　　处：《中国当代医药》2024年第33期188-193,198,共7页China Modern Medicine

基　　金：国家级大学生创新训练项目(202210601057)。

摘　　要：复发性阿弗他口腔溃疡,中医俗称“口疮”,是临床上最常见的口腔黏膜类疾病,具有明显的周期性和自限性特点,常累及唇、颊、舌、软腭及口角等部位的黏膜组织。其病变部位中心凹陷,周围红肿,表面覆盖灰黄色或者灰白色假膜。复发性阿弗他口腔溃疡的病因尚未明确,与诸多因素相关。目前主要认为免疫力低下、微生物感染、微量元素缺乏、家族性遗传等因素与复发性阿弗他口腔溃疡的发生具有密切关系。临床上尚无特效药物进行治疗,因此仍以对症治疗为主。本文将基于复发性阿弗他口腔溃疡的病因,从全身性系统用药、局部用药及新型治疗技术方面总结目前的治疗方法,并对当下复发性阿弗他口腔溃疡最新的研究靶点及免疫标志物进行综述,以期为临床医生和科研人员应用及研发口腔溃疡治疗药物提供理论依据。Recurrent aphthous ulcer,commonly known as"mouth ulcer"in traditional Chinese medicine,is the most common oral mucosal disease in clinical practice,with obvious periodic and self-limited characteristics,often involving the lips,cheeks,tongue,soft palate and oral corner mucosal tissue.The central part of the lesion is sunken,the surrounding is red and swollen,and the surface is covered with grayish yellow or grayish white false film.The etiology of recurrent aphthous ulcer is not clear,and it is related to many factors.At present,it is believed that low immunity,microbial infection,trace element deficiency,familial inheritance and other factors are closely related to the occurrence of recurrent aphthous ulcer.There is no specific drug for clinical treatment,so symptomatic treatment is still the main treatment.This article is based on the etiology of recurrent aphthous ulcer,from the systemic medication,topical medication and new treatment technologies of current therapies were summarized,and the latest research targets and immune markers of recurrent aphthous ulcer were reviewed,in order to provide theoretical basis for clinical doctors and researchers to apply and develop drugs for the treatment of oral ulcer.

关 键 词：口腔溃疡 病因 分型 治疗方法 药物 局部用药 系统用药 

分 类 号：R781.5[医药卫生—口腔医学]