高压氧联合养血解郁醒脑汤治疗急性脑梗死后睡眠障碍患者的疗效观察  

Observation on the efficacy of hyperbaric oxygen combined with Yangxue Jieyu Xingnao Decoction in treatment of sleep disorder patients after acute cerebral infarction

作　　者：吴小培 杨晓丽 吕霞 江丽 WU Xiaopei;YANG Xiaoli;LYU Xia;JIANG Li(Department of Geriatric Medicine,Hai′an People′s Hospital,Jiangsu 226600,China;Department of Neurology,Hai′an People′s Hospital,Jiangsu 226600,China)

机构地区：[1]海安市人民医院老年医学科,江苏226600 [2]海安市人民医院神经内科,江苏226600

出　　处：《中国临床新医学》2024年第11期1262-1266,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：南通市基础研究和民生科技计划指导性项目(编号:MSZ21051)。

摘　　要：目的探讨高压氧联合养血解郁醒脑汤对急性脑梗死后睡眠障碍患者睡眠质量的影响。方法招募2022年1月至12月海安市人民医院收治的160例急性脑梗死后睡眠障碍患者,采用随机数字表法将其分为对照组和观察组,各80例。对照组给予高压氧治疗,观察组给予高压氧联合养血解郁醒脑汤治疗。两组连续治疗4周,于治疗结束后比较两组疗效。结果治疗后,两组匹兹堡睡眠质量指数评定量表(PSQI)评分及Epworth嗜睡量表(ESS)评分低于治疗前,观察组PSQI评分及ESS评分低于对照组,两组总睡眠时间(TST)、快速眼球运动睡眠时间(RT)长于治疗前,睡眠潜伏期(SL)短于治疗前,观察组TST、RT长于对照组,SL短于对照组,两组血清去甲肾上腺素(NE)、5-羟色胺(5-HT)水平高于治疗前,观察组血清NE、5-HT水平高于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组(93.75%vs 78.75%;χ^(2)=7.589,P=0.006)。治疗期间,两组均未出现过敏、肝肾损伤等严重不良反应。结论高压氧联合养血解郁醒脑汤可以有效提升急性脑梗死后睡眠障碍患者的睡眠质量,且安全性良好。Objective To explore the effect of hyperbaric oxygen combined with Yangxue Jieyu Xingnao Decoction on sleep quality of patients with sleep disorders after acute cerebral infarction.Methods A total of 160 patients with sleep disorders after acute cerebral infarction who were admitted to Hai′an People′s Hospital from January 2022 to December 2022 were recruited.The patients were divided into control group and observation group by random number table method,with 80 cases in each group.The control group was given hyperbaric oxygen treatment,and the observation group was given hyperbaric oxygen combined with Yangxue Jieyu Xingnao Decoction treatment.Both groups were given continuous treatment for 4 weeks,and the therapeutic efficacy was compared between the two groups after the end of treatment.Results The Pittsburgh Sleep Quality Index(PSQI)rating scale scores and Epworth Sleepiness Scale(ESS)scores after treatment were lower than those before treatment in the two groups,and the PSQI scores and ESS scores in the observation group were lower than those in the control group after treatment,and the total sleep time(TST)and rapid eye movement sleep time(RT)after treatment was longer than that before treatment in the two groups,and the sleep latency(SL)after treatment was shorter than that before treatment in the two groups,and the TST and RT in the observation group was longer than that in the control group,and the SL in the observation group was shorter than that in the control group after treatment.The serum levels of norepinephrine(NE)and 5-hydroxytryptamine(5-HT)after treatment were higher than those before treatment in the two groups,and the serum levels of NE and 5-HT in the observation group were higher than those in the control group after treatment,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group(93.75%vs 78.75%;χ^(2)=7.589,P=0.006).During the treatment,there were no serious adverse reactions such as allerg

关 键 词：急性脑梗死 睡眠障碍 高压氧 养血解郁醒脑汤 睡眠质量 

分 类 号：R743[医药卫生—神经病学与精神病学]