程玲教授自拟加减蛇床子散外洗幼女外阴硬化性苔藓的疗效观察  

Clinical Efficacy of Modified Shechuangzi Powder by Professor Cheng Ling in Treatment of Vulvar Lichen Sclerosus in Young Girls

作　　者：温利娟 程玲[2] 王浩[2] WEN Li-juan;CHENG Ling;WANG Hao(Maternal and Child Health Hospital in Shunyi District/Shunyi Women's&Children's Hospital of Beijing Children's Hospital,Beijing 101300;Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102)

机构地区：[1]北京市顺义区妇幼保健院/北京儿童医院顺义妇儿医院,北京101300 [2]中国中医科学院望京医院,北京100102

出　　处：《世界中西医结合杂志》2024年第11期2193-2197,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：北京市程玲中医妇幼名医传承工作室建设项目(2022-FYGZS-25)。

摘　　要：目的观察程玲教授自拟加减蛇床子散外洗幼女外阴硬化性苔癣(Vulvar lichen sclerosus,VLS)的临床疗效。方法选取2019年12月—2022年12月期间于北京市顺义区妇幼保健院小儿妇科门诊就诊的VLS患儿68例,按随机数字表法分为对照组和治疗组,每组各34例。对照组给予丁酸氢化可的松乳膏治疗,治疗组给予程玲教授自拟加减蛇床子散联合丁酸氢化可的松乳膏治疗。治疗12周后,观察比较两组患儿临床疗效、复发率、不良反应情况,治疗前后临床症状评分、体征评分、谢-川岛瘙痒严重度评分、皮肤评分。结果治疗1个月后,两组患儿皮肤颜色、谢-川岛(日间、夜间)评分均较治疗前降低,差异有统计学意义(P<0.05);两组患儿皮肤弹性评分与治疗前比较,差异无统计学意义(P>0.05);两组患儿治疗1个月后皮肤颜色、皮肤弹性、谢-川岛(日间、夜间)评分组间比较,差异无统计学意义(P>0.05)。治疗3个月后,两组患儿皮肤颜色、皮肤弹性、谢-川岛(日间、夜间)评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组皮肤颜色、谢-川岛(日间、夜间)评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后治疗组总有效率94.12%(32/34)明显高于对照组85.29%(29/24),差异有统计学意义(P<0.05)。随访期间,治疗组复发率5.88%(2/34)明显低于对照组17.65%(6/34),差异有统计学意义(P<0.05)。治疗期间,两组患儿均未出现血常规、肝肾功能、心电图异常等不良反应情况。结论程玲教授自拟加减蛇床子散外洗幼女VLS有较好的临床疗效,能在较短时间内改善瘙痒症状及皮肤颜色,且复发率较小。Objective To evaluate the clinical efficacy of Professor Cheng Ling's modified Shechuangzi Powder in the treatment of vulvar lichen sclerosus(VLS)in young girls.Methods A total of 68 pediatric patients diagnosed with VLS who visited the pediatric gynecology clinic at the Maternal and Child Health Hospital in Shunyi District,Beijing,between December 2019 and December 2022 were enrolled and randomly divided into a control group and a treatment group using a random number table,with 34 cases in each group.The control group was treated with hydrocortisone butyrate cream,while the treatment group received Professor Cheng Ling's modified Shechuangzi Powder combined with hydrocortisone butyrate cream.After 12 weeks of treatment,the clinical efficacy,recurrence rate,and adverse reactions were compared between the two groups.Additionally,clinical symptom scores,physical sign scores,the Xie-Kawashima itch severity scores,and skin scores were assessed before and after treatment.Results After one month of treatment,the skin color and Xie-Kawashima(daytime and nighttime)scores in both groups significantly improved compared to baseline(P<0.05),with no significant difference in skin elasticity scores compared to baseline(P>0.05).There were no significant differences between the two groups in skin color,skin elasticity,or Xie-Kawashima(daytime and nighttime)scores after one month of treatment(P>0.05).After three months of treatment,both groups showed significant improvements in skin color,skin elasticity,and Xie-Kawashima(daytime and nighttime)scores compared to baseline(P<0.05).Furthermore,the treatment group exhibited significantly greater reductions in skin color and Xie-Kawashima(daytime and nighttime)scores than the control group(P<0.05).The total effective rate in the treatment group was 94.12%(32/34),significantly higher than the 85.29%(29/34)in the control group(P<0.05).During the follow-up period,the recurrence rate in the treatment group was 5.88%(2/34),which was significantly lower than 17.65%(6/34)in the control grou

关 键 词：蛇床子散 糖皮质激素 幼女 外阴硬化性苔藓 

分 类 号：R364.32[医药卫生—病理学]