Non‑Enzyme,Temperature Calibrating,and Bioactive Fiber‑based Flexible Sensors for Dopamine and Lactic Acid Detection  

作　　者：Maowen Xie Guang Yao Xingyi Gan Chunhong Zhang Tianyao Zhang Qian Wang Xinqin Li Chenzheng Zhou Kangning Zhao Min Gao Taisong Pan Yuan Lin 

机构地区：[1]School of Materials and Energy,University of Electronic Science and Technology of China,Chengdu 610054,Sichuan,China [2]State Key Laboratory of Electronic Thin Films and Integrated Devices,University of Electronic Science and Technology of China,Chengdu 610054,Sichuan,China [3]Medico‑Engineering Cooperation on Applied Medicine Research Center,University of Electronic Science and Technology of China,Chengdu 610054,Sichuan,China [4]Shenzhen Institute for Advanced Study,University of Electronic Science and Technology of China,Shenzhen 518110,China [5]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,International School of Materials Science and Engineering,Wuhan University of Technology,Wuhan 430070,Hubei,China

出　　处：《Advanced Fiber Materials》2024年第2期501-511,共11页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China under Grant numbers 61825102,62371115,62001096,U21A20460,52021001;Science and Technology Major Project of Tibetan Autonomous Region of China under grant no.XZ202201ZD0001G;and the Medico-Engineering Cooperation Funds,Fundamental Research Funds for the Central Universities,UESTC under Grant nos.ZYGX2020ZB041,ZYGX2021YGLH002,and ZYGX2021YGLH007.

摘　　要：Flexible electrochemical biosensors enable the in-situ monitoring and quantification of human biochemical constituents in molecular scale,spearheading and thriving the field toward precision medicine.However,specific biorecognition elements for multiplexed biomarkers detection,temperature stability and versatility need to be improved for higher adaption.Here,we propose a bioactive sensor patch comprising a non-enzyme Co_(3)O_(4)/carbon fiber-based biorecognition element and a temperature calibration unit.The optimized serpentine configuration renders the sensor intimate and seamless attachment with skin,operating robustly even subjected to 40%tensile strain.The fiber-based sensor could selectively monitor dopa-mine and lactic acid contents based on cyclic voltammetry and amperometry,respectively.The bioanalytical results at room temperature indicate that the electrochemical biosensor has a wide detection range(0.001–1.100 mM for dopamine and 2–35 mM for lactic acid),excellent selectivity and reproducibility(maximum error 3.2%for dopamine and 5.6%for lactic acid).In addition,temperature calibration contour maps of these two biomarkers are established in an ambient temperature range from 25 to 45℃.The continuously collected data could be aggregated and wirelessly transmitted to portable devices using an electrochemical signal transducer and an acquisition module,promising personalized and preventative health care in various scenarios.

关 键 词：Bioactive fiber Electrochemical selectivity DOPAMINE Lactic acid Temperature calibration SENSOR 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]