肠道菌群在葡萄膜炎中的作用与研究进展  

Role and research progress of gut microbiota in uveitis

作　　者：林映橙 胡秋明[1,2] 周敏 刘锦清[1] Lin Yingcheng;Hu Qiuming;Zhou Min;Liu Jinqing(Guangxi University of Chinese Medicine,Nanning 530220,Guangxi Zhuang Autonomous Region,China;Guangxiyida Jingliang Eye Hospital,Nanning 530000,Guangxi Zhuang Autonomous Region,China;Department of Ophthalmology,Taoyuan Hospital of Traditional Chinese Medicine,Taoyuan 415700,Hunan Province,China)

机构地区：[1]广西中医药大学,广西壮族自治区南宁市530220 [2]广西医大晶亮眼科医院,广西壮族自治区南宁市530000 [3]中国湖南省桃源县中医医院眼科,415700

出　　处：《国际眼科杂志》2025年第1期64-69,共6页International Eye Science

摘　　要：葡萄膜炎是一种涉及眼部多个结构的致盲性炎性疾病,严重时威胁患者的视力和心理健康。目前,针对葡萄膜炎的治疗以糖皮质激素以及免疫抑制剂为主,其存在副作用较多、易复发且治疗费用高昂等问题。近年来的研究表明,肠道菌群可通过肠-眼轴在葡萄膜炎的发展中起作用,其相关代谢物也对该疾病的进展具有重要影响,调节肠道菌群或相关代谢物可能成为治疗葡萄膜炎的新途径。文章综述了肠道菌群与各葡萄膜炎相关疾病如系统性结节病、Vogt-小柳原田病、白塞病、多发性硬化症、鸟枪弹样葡萄膜炎的联系,介绍益生菌和益生元、抗生素、免疫调节剂、噬菌体疗法和粪便微生物移植等菌群相关治疗的研究进展,旨在为推动针对葡萄膜炎特异菌群及相关基因标志物的新疗法发展提供参考,促进精准医疗的实现。Uveitis is a blinding inflammatory disease that affects multiple structures within the eye,posing significant risks to patients' vision and mental health.Current treatments mainly involve glucocorticoids and immunosuppressants,which are associated with significant side effects,high relapse rates,and substantial costs.Recent research suggests that the gut microbiota may play a role in the development of uveitis through the gut-eye axis,with related metabolites also influencing disease progression.Modulating the gut microbiota or its metabolites could offer new therapeutic avenues for uveitis.This review explores the relationship between gut microbiota and various uveitis-associated diseases,such as systemic sarcoidosis,Vogt-Koyanagi-Harada syndrome,Behcet's disease,multiple sclerosis,and birdshot chorioretinopathy.It also discusses advancements in microbiota-related therapies,including probiotics and prebiotics,antibiotics,immunomodulators,phage therapy,and fecal microbiota transplantation.The aim is to provide a reference for the development of new therapies targeting specific microbial communities and genetic markers associated with uveitis,thereby promoting the realization of precision medicine.

关 键 词：肠道菌群 葡萄膜炎 肠-眼轴 鸟枪弹样葡萄膜炎 噬菌体疗法 粪便微生物移植 

分 类 号：R773[医药卫生—眼科]