Wnt信号通路在近视发病中作用及机制的研究进展  

Research progress on the role and mechanism of Wnt signaling pathway in the pathogenesis of myopia

作　　者：王泽 颉瑞萍 刘雪 Wang Ze;Xie Ruiping;Liu Xue(School of Clinical Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730020,Gansu Province,China;Department of Ophthalmology,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃省兰州市730000 [2]甘肃中医药大学附属医院眼科,甘肃省兰州市730020

出　　处：《国际眼科杂志》2025年第1期99-103,共5页International Eye Science

基　　金：甘肃省自然科学基金项目(No.22JR11RA130);甘肃省名中医传承工作室建设项目[No.甘中医药发(2024)7号]。

摘　　要：近视是全球范围内日益严重的公共卫生问题,其发病机制复杂,涉及多种信号通路和基因的相互作用。Wnt信号通路在细胞增殖、分化和凋亡,以及组织重塑等生物学过程中发挥着重要作用,近年来其在近视发病中的作用逐渐受到关注。研究表明,Wnt信号通路通过调节视网膜细胞(包括RPE细胞和ipRGCs)的增殖、分化和凋亡,以及巩膜成纤维细胞的增殖和细胞外基质成分(如Ⅰ型胶原蛋白)的表达,进而影响巩膜重塑和眼轴增长,最终影响近视的发生发展。文章总结了不同眼组织(视网膜和巩膜)中Wnt信号通路在近视发生发展中的作用并在此基础上对基于Wnt信号通路的近视防治策略进行了探讨,以期为近视相关机制研究及临床治疗提供思路。·Myopia is an increasingly prevalent public health concern globally,with a complex pathogenesis involving the interplay of multiple signaling pathways and genes.The Wnt signaling pathway plays a crucial role in biological processes such as cell proliferation,differentiation,apoptosis,and tissue remodeling,and its role in myopia development has garnered significant attention in recent years.Studies have demonstrated that the Wnt signaling pathway influences the occurrence and progression of myopia by regulating the proliferation,differentiation,and apoptosis of retinal cells(including RPE cells and ipRGCs),as well as the proliferation of scleral fibroblasts and the expression of extracellular matrix components(such as type I collagen),thereby affecting scleral remodeling and axial length elongation.This paper summarizes the roles of the Wnt signaling pathway in myopia development within different ocular tissues(retina and sclera) and explores potential myopia prevention and treatment strategies based on this pathway,providing insights for further research and clinical management of myopia.

关 键 词：近视 WNT信号通路 发病机制 巩膜 视网膜细胞 

分 类 号：R778.11[医药卫生—眼科]