血清LRG1及FGF-21水平与新生血管性青光眼的相关性  

Correlation of serum leucine-rich α-2 glycoprotein 1 and fibroblast growth factor 21 levels with neovascular glaucoma

作　　者：罗忠 周鹤 黄怡 董万江 Luo Zhong;Zhou He;Huang Yi;Dong Wanjiang(Mianyang Wanjiang Eye Hospital,Mianyang 621000,Sichuan Province,China)

机构地区：[1]绵阳万江眼科医院,四川省绵阳市621000

出　　处：《国际眼科杂志》2025年第1期118-121,共4页International Eye Science

基　　金：四川省卫生健康委员会科研课题(No.19PJ219)。

摘　　要：目的:探讨血清富亮氨酸α-2糖蛋白1(LRG1)、成纤维细胞生长因子21(FGF-21)水平与新生血管性青光眼(NVG)的相关性。方法:选取2020-09/2022-09本院眼科收治的110例110眼NVG患者为NVG组(Ⅱ级23例、Ⅲ级44例、Ⅳ级43例),性别、年龄相匹配的白内障患者90例90眼为对照组。ELISA检测血清中LRG1、FGF-21、血管内皮生长因子(VEGF)、色素上皮衍生因子(PEDF)及肿瘤坏死因子-α(TNF-α)水平;Pearson相关性分析血清LRG1、FGF-21水平与Teich分级、VEGF、PEDF、TNF-α水平的相关性。结果:NVG组与对照组相比,血清LRG1、FGF-21、VEGF、PEDF、TNF-α水平显著升高(均P<0.01)。随着Teich分级的增加,NVG患者血清LRG1、FGF-21、VEGF、PEDF、TNF-α水平依次显著升高(均P<0.05)。NVG患者血清中LRG1、FGF-21水平与VEGF、PEDF、TNF-α水平呈正相关(均P<0.05)。结论:NVG患者血清LRG1、FGF-21水平显著升高,与VEGF、PEDF及TNF-α水平正相关,二者可能与NVG的发生有关。·AIM:To investigate the correlation of serum leucine-rich α-2 glycoprotein 1(LRG1) and fibroblast growth factor 21(FGF-21) levels with neovascular glaucoma(NVG).·METHODS:A total of 110 cases(110 eyes) with NVG admitted to the ophthalmology department from September 2020 to September 2022 were selected as NVG group,with 23 cases of grade Ⅱ,44 cases of grade Ⅲ,and 43 cases of grade Ⅳ,while 90 sex and age matched cataract patients(90 eyes) were selected as control group.The levels of LRG1,FGF-21,vascular endothelial growth factor(VEGF),pigment epithelium-derived factor(PEDF),and tumor necrosis factor-α(TNF-α) in serum were detected by ELISA;Pearson correlation analysis was used to analyze the correlation of serum LRG1 and FGF-21 levels with Teich grade,VEGF,PEDF and TNF-α levels.·RESULTS:The levels of serum LRG1,FGF-21,VEGF,PEDF and TNF-α in the NVG group were significantly higher than those in the control group(all P<0.01).With the increase of Teich grading,the levels of serum LRG1,FGF-21,VEGF,PEDF and TNF-α in NVG patients significantly increased in turn(all P<0.05).Correlation analysis showed that the levels of LRG1 and FGF-21 in serum of NVG patients were positively correlated with the levels of VEGF,PEDF and TNF-α(all P<0.05).·CONCLUSION:The levels of LRG1 and FGF-21 in serum of patients with NVG are obviously increased,which are positively correlated with the levels of VEGF,PEDF and TNF-α,both of which may be related to the development of NVG.

关 键 词：新生血管性青光眼 富亮氨酸α-2糖蛋白1(LRG1) 成纤维细胞生长因子21(FGF-21) Teich分级 相关性 

分 类 号：R775.3[医药卫生—眼科]