单侧视网膜分支静脉阻塞患者视盘区微血管的量化分析  

Quantitative analysis on microvasculature in the optic disc area of patients with unilateral branch retinal vein occlusion

作　　者：孙佳 刘健 燕鹏 陆楠 单志明[1] 杨冬妮[1] Sun Jia;Liu Jian;Yan Peng;Lu Nan;Shan Zhiming;Yang Dongni(Department of Ophthalmology,First Hospital of Qinhuangdao,Qinhuangdao 066000,Hebei Province,China;School of Control Engineering,Northeastern University at Qinhuangdao,Qinhuangdao 066000,Hebei Province,China)

机构地区：[1]中国河北省秦皇岛市第一医院眼科,河北省秦皇岛市066000 [2]东北大学秦皇岛分校控制工程学院,河北省秦皇岛市066000

出　　处：《国际眼科杂志》2025年第1期152-156,共5页International Eye Science

摘　　要：目的:观察单侧视网膜分支静脉阻塞(BRVO)患者视网膜神经纤维层(RNFL)厚度,视盘周围放射状毛细血管(RPC)密度的变化,并进一步分析RPC密度与RNFL厚度的关系。方法:观察性研究。选取2020-10/2022-01在秦皇岛市第一医院眼科确诊的单侧BRVO患者37例,37只患眼为单侧BRVO组,37只对侧健眼为对侧健眼组,同时期无眼部疾病健康者35名35眼(均选取右眼入组)作为健康对照组。所有参与者双眼均行最佳矫正视力、眼压、眼前节、眼底及光相干断层扫描血管成像(OCTA)检查。使用OCTA设备自带软件测量黄斑中心凹厚度(CMT)、RNFL厚度和视盘中心到动静脉交叉点的距离(DAVD)。采用优化的U-net算法剔除视盘周围大血管后再计算RPC密度。比较三组间CMT、RNFL厚度、RPC密度,并分析RPC密度与CMT、RNFL厚度、DAVD之间的相关性。结果:单侧BRVO组患眼CMT、RNFL厚度较对侧健眼组和健康对照组显著增厚(均P<0.05);对侧健眼组CMT、RNFL厚度与健康对照组比较均无差异(均P>0.05)。单侧BRVO组患眼RPC密度较对侧健眼组增加,较健康对照组减少,但均无差异(均P>0.05),而对侧健眼组RPC密度较健康对照组减少(P<0.05)。单侧BRVO组患眼RPC密度与CMT无相关性(P=0.960),与RNFL厚度呈正相关(r=0.401,P=0.014),与DAVD呈负相关(r=-0.339,P=0.040)。结论:BRVO患眼视盘区RNFL明显增厚、RPC密度无明显变化。RPC密度与RNFL厚度呈正相关,说明RNFL厚度可作为分析研究RPC密度损伤程度的监测指标。·AIM:To observe the changes of retinal nerve fiber layer(RNFL) thickness and radial peripheral capillary(RPC) density in patients with unilateral branch retinal vein occlusion(BRVO),and further analyze the correlation between RPC density and RNFL thickness.·METHODS:Observational study.Totally 37 patients with unilateral BRVO diagnosed at the ophthalmology department of First Hospital of Qinhuangdao from October 2020 to January 2022 were selected,the 37 affected eyes were the unilateral BRVO group,and 37 fellow healthy eyes were the contralateral unaffected group,and 35 healthy individuals(35 right eyes were selected) without ocular diseases during the same period were selected as the normal control group.The best corrected visual acuity,intraocular pressure,anterior segment,fundus and optical coherence tomography angiography(OCTA) were examined in both eyes of all BRVO patients and healthy individuals.The central macular thickness(CMT),the RNFL thickness,and the optic disc-AV crossing distance(DAVD) were measured by built-in software of the OCTA equipment.The optimized U-net algorithm was used to eliminate the large blood vessels,and then the RPC density was calculated.The CMT,RNFL thickness and RPC density were compared among the three groups.And the correlations of the RPC density with the CMT,RNFL thickness,and the DAVD were investigated.·RESULTS:Compared with the contralateral unaffected group and the normal control group,the CMT and the RNFL thickness were significantly thickened in the unilateral BRVO group(all P<0.05);there were no statistical differences in the CMT and the RNFL thickness between the contralateral unaffected group and the normal control group(all P>0.05).The RPC density in the unilateral BRVO group increased compared with the contralateral unaffected group and decreased compared with the normal control group,but there was no statistically difference(all P>0.05).However,the RPC density in the contralateral unaffected group decreased compared with the normal control group(P<0.05).The RPC

关 键 词：视网膜分支静脉阻塞 光相干断层扫描血管成像 视盘周围放射状毛细血管密度 视网膜神经纤维层厚度 视盘中心到动静脉交叉点的距离 

分 类 号：R774.1[医药卫生—眼科]