孤立性双侧外展神经麻痹病因学分析  

Etiological Analysis of Isolated Bilateral Abductor Nerve Paralysis

作　　者：刘同岩 李元 周凌云[2] LIU Tongyan;LI Yuan;ZHOU Lingyun(Heilongjiang University of Traditional Chinese Medicine,Harbin 150006,China;Department of Acupuncture and moxibustion,Harbin Medical University Afiliated First Hospital,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150006 [2]哈尔滨医科大学附属第一医院针灸科,哈尔滨150001

出　　处：《神经损伤与功能重建》2024年第12期788-792,共5页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金项目(基于miR-21调控巨噬细胞极化眶内电针促进动眼神经损伤后修复机制的研究,No.82074524);黑龙江中医药大学研究生创新科研项目(眶内电针调控miR-21/JNK/p53通路促进动眼神经损伤大鼠神经元突触重塑机制研究,No.2024yjscx103)。

摘　　要：孤立性双侧外展神经麻痹是一种双侧外展神经同时受损而不伴有其他颅神经损害的病症,临床表现以视物双影、双眼外转运动受限为特征。既往文献类型以个案报道为主,涉及到的病因及病理机制繁杂且说法不一。本文侧重于孤立性双侧外展神经麻痹,基于近10年国内外双侧外展神经麻痹有关文献报道,对双侧外展神经麻痹病因、病理机制以及鉴别诊断进行分析,将其病因归纳为继发性、先天性及特发性三大类,病理机制概括为过度牵拉、直接压迫、血液神经毒性物质、营养缺乏、供血障碍等进行分析。以期为双侧外展神经麻痹的病因学研究及临床诊疗提供思路。Isolated bilateral abducens nerve palsy is a condition characterized by simultaneous damage to both abducens nerves without involvement of other cranial nerves,with clinical manifestations primarily featuring double vision and limited outward movement of both eyes.Previous literature mainly consists of case reports,involving complex and varying etiologies and pathological mechanisms.This article focuses on isolated bilateral abducens nerve palsy,analyzing the causes,pathological mechanisms,and differential diagnosis based on domestic and international literature reports on bilateral abducens nerve palsy over the past decade.The etiologies are categorized into three major types:secondary,congenital,and idiopathic.Pathological mechanisms include excessive traction,direct compression,blood-neurotoxic substances,nutritional deficiencies,and vascular supply disorders.The aim is to provide insights for the etiological research and clinical diagnosis and treatment of bilateral abducens nerve palsy.

关 键 词：双侧外展神经麻痹 孤立性 病因学 综述 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R745