依达拉奉右莰醇联合阿托伐他汀治疗缺血性脑血管病合并颈动脉粥样硬化的疗效  

Effect of edaravone and dextrcamphor combined with atorvastatin on ischemic cerebrovascular disease with carotid atherosclerosis

作　　者：张亮 马晓蕾 闫秋华 ZHANG Liang;MA Xiao-lei;YAN Qiu-hua(Department of Neurology,People's Hospital of Bayingolin Mongolian Autonomous Prefecture,Korla 841000,Xinjiang,China)

机构地区：[1]新疆巴音郭楞蒙古自治州人民医院神经内科,新疆库尔勒市841000

出　　处：《川北医学院学报》2024年第12期1709-1712,共4页Journal of North Sichuan Medical College

摘　　要：目的:探究依达拉奉右莰醇联合阿托伐他汀治疗缺血性脑血管病(ICVD)合并颈动脉粥样硬化(CAS)的疗效。方法:纳入266例ICVD合并CAS患者为研究对象,根据治疗方式不同分为A、B两组。A组患者使用阿托伐他汀治疗;B组患者使用依达拉奉右莰醇+阿托伐他汀治疗。两组患者均连续治疗14 d。对比两组患者的临床疗效及治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)和CAS情况。结果:B组患者总有效率(94.74%)高于A组(85.71%)(P<0.05);治疗后,两组患者NIHSS评分均降低(P<0.05),且B组低于A组(P<0.05);两组患者MIT、斑块直径及数量均降低(P<0.05),且B组低于A组(P<0.05);两组患者BI评分均升高(P<0.05),且B组高于A组(P<0.05)。结论:依达拉奉右莰醇联合阿托伐他汀治疗ICVD合并CAS的临床疗效确切,可有效改善患者的神经功能评分和CAS情况,提高患者的日常生活能力。Objective:To analyze the efficacy of edaravone dexcamphenol combined with atorvastatin in the treatment of ischemic cerebrovascular disease(ICVD)complicated with carotid atherosclerosis(CAS).Methods:266 patients with ICVD combined with CAS were selected and divided into two groups,group A received atorvastatin,group B received Edaravone dextrocamphorol+atorvastatin,and both groups received continuous treatment for 14 days.The clinical curative effect,national institutes of health stroke scale(NIHSS)scores,Barthel index(BI)and CAS before and after treatment were compared between the two groups.Results:The total effective rate of group B was higher than that of group A(94.74%vs.85.71%,P<0.05).Compared with the two groups before treatment,the NIHSS score after treatment was decreased(P<0.05),and group B was lower than group A(P<0.05).The MIT,plaque diameter and number of two groups after treatment were decreased(P<0.05),and group B was lower than group A(P<0.05).BI scores in both groups were higher after treatment(P<0.05),and those in group B were higher than those in group A(P<0.05).Conclusion:Edaravone dexcamphenol combined with atorvastatin has definite clinical efficacy in the treatment of ICVD complicated with CAS,which can effectively improve the neurological function score and CAS situation of patients,and improve the ability of daily living of patients.

关 键 词：依达拉奉右莰醇 阿托伐他汀 缺血性脑血管病 颈动脉粥样硬化 

分 类 号：R743[医药卫生—神经病学与精神病学]