Lipocalin-2 and intestinal diseases  

作　　者：Zhong-Xu Zhang Jian Peng Wei-Wei Ding 

机构地区：[1]Department of Trauma and Acute Care Surgery,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210002,Jiangsu Province,China

出　　处：《World Journal of Gastroenterology》2024年第46期4864-4879,共16页世界胃肠病学杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82270587.

摘　　要：Dysfunction of the intestinal barrier is a prevalent phenomenon observed across a spectrum of diseases,encompassing conditions such as mesenteric artery dissection,inflammatory bowel disease,cirrhosis,and sepsis.In these pathological states,the integrity of the intestinal barrier,which normally serves to regulate the selective passage of substances between the gut lumen and the bloodstream,becomes compromised.This compromised barrier function can lead to a range of adverse consequences,including increased permeability to harmful substances,the translocation of bacteria and their products into systemic circulation,and heightened inflammatory responses within the gut and beyond.Understanding the mechanisms underlying intestinal barrier dysfunction in these diverse disease contexts is crucial for the development of targeted therapeutic interventions aimed at restoring barrier integrity and ameliorating disease progression.Lipocalin-2(LCN2)expression is significantly upregulated during episodes of intestinal inflammation,making it a pivotal indicator for gauging the extent of such inflammatory processes.Notably,however,LCN2 derived from distinct cellular sources,whether intestinal epithelial cells or immune cells,exhibits notably divergent functional characteristics.Furthermore,the multifaceted nature of LCN2 is underscored by its varying roles across different diseases,sometimes even demonstrating contradictory effects.

关 键 词：Lipocalin-2 Neutrophil gelatinase-associated lipocalin Intestinal barrier IMMUNITY Gastrointestinal diseases Ferroptosis Neutrophil extracellular traps 

分 类 号：R563.1[医药卫生—呼吸系统]