Should we pay more attention to the potential link between Helicobacter pylori and esophageal cancer in Asian countries  

作　　者：Jie Liu Ying-Ling Liu 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,Anhui Province,China

出　　处：《World Journal of Gastroenterology》2024年第46期4958-4963,共6页世界胃肠病学杂志（英文）

基　　金：Supported by Research Project of the Chinese Digestive Early Cancer Physicians'Joint Growth Program,No.GTCZ-2021-AH-34-0012;Lu'an Science and Technology Plan Project,No.2022lakj040.

摘　　要：The presence of Helicobacter pylori(H.pylori)infection has been indicated to have a protective influence on esophageal cancer(EC)in some studies,but its specific impact on the risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma remains inconclusive.This manuscript comment addresses the recent study by López-Gómez et al.Despite it was a retrospective observational study without a control group,this study revealed a notably low prevalence of H.pylori infection among EC patients,indicating a potential association between H.pylori and EC in Spain.It is important to note that the relationship between H.pylori and the risk of EC varies geographically.We also conducted a metaanalysis focusing on this association in Asian populations to offer precise clinical insights.However,no significant correlation between H.pylori infection and EC was identified,suggesting that the perceived protective effect of H.pylori against EC may have been overestimated in the Asian population.

关 键 词：Helicobacter pylori Esophageal cancer Proton pump inhibitors ASIAN Metaanalysis 

分 类 号：R735.2[医药卫生—肿瘤]