Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease  

作　　者：Anis Hasnaoui Racem Trigui Mario Giuffrida 

机构地区：[1]Faculty of Medicine of Tunis,Tunis El Manar University,Bab Saadoun Tunis 1007,Tunisia [2]Department of General Surgery,Menzel Bourguiba Hospital,Menzel Bourguiba 7050,Bizerte,Tunisia [3]Department of General Surgery,Guglielmo da Saliceto Hospital,Piacenza 29100,Italy

出　　处：《World Journal of Gastroenterology》2024年第46期4969-4976,共8页世界胃肠病学杂志（英文）

摘　　要：In this letter,we commented on the article by Wu et al.We examined the interactions between mesenteric adipose tissue,creeping fat,and gut microbiota in Crohn’s disease(CD),a condition marked by chronic gastrointestinal inflammation with a rising global incidence.The pathogenesis of CD involves complex genetic,environmental,and microbial factors.Dysbiosis,which is an imbalance in gut microbial communities,is frequently observed in CD patients,highlighting the pivotal role of the gut microbiota in disease progression and the inflammatory response.Recent studies have shown that mesenteric adipose tissue and creeping fat actively contribute to inflammation by producing proinflammatory cytokines.The relationship between creeping fat and altered microbiota can shift from a potentially protective role to one that encourages bacterial translocation,further complicating disease management.Recent research has suggested that fecal microbiota transplantation could help restore microbial balance,offering a promising therapeutic strategy to improve clinical disease response.

关 键 词：Crohn’s disease Intestinal microbiota DYSBIOSIS Intestinal barrier Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation 

分 类 号：R657.1[医药卫生—外科学]