Prevalence and associated risk factors of Helicobacter pylori infection in community households in Lanzhou city  

作　　者：Ju-Kun Zhou Ya Zheng Yu-Ping Wang Rui Ji 

机构地区：[1]The First Clinical Medical College,Lanzhou University,Lanzhou 730000,Gansu Province,China [2]Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China [3]Gansu Province Clinical Research Center for Digestive Diseases,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China

出　　处：《World Journal of Gastroenterology》2024年第47期5018-5031,共14页世界胃肠病学杂志（英文）

基　　金：Supported by The Lanzhou Talent Innovation and Entrepreneurship Project,China,No.2019-RC-33;The Medical Innovation and Development Project of Lanzhou University,China,No.lzuyxcx-2022-184.

摘　　要：BACKGROUND Helicobacter pylori(H.pylori)infection exhibits a familial clustering phenomenon.AIM To investigate the prevalence of H.pylori infection,identify associated factors,and analyze patterns of transmission within families residing in the community.METHODS From July 2021 to September 2021,a total of 191 families(519 people)in two randomly chosen community health service centers in the Chengguan District of Lanzhou in Gansu Province,were recruited to fill out questionnaires and tested for H.pylori infection.Individuals were followed up again from April 2023 and June 2023 to test for H.pylori infection.The relationship between variables and H.pylori infection was analyzed using logistic regression and generalized linear mixed models.RESULTS In 2021,the individual-based H.pylori infection rate was found to be 47.0%(244/519),which decreased to 38.1%(177/464)in 2023.Additionally,the rate of individual-based H.pylori new infection was 22.8%(55/241).The family-based H.pylori infection rate in 2021 was 76.9%(147/191),which decreased to 67.1%(116/173)in 2023,and the rate of family-based H.pylori new infection was 38.6%(17/44).Individual H.pylori infection was positively correlated with age,body mass index(BMI),eating food that was excessively hot,frequent acid reflux,bloating,and halitosis symptoms,and negatively correlated with family size and nut consumption.New individual H.pylori infection was positively correlated with BMI,other types of family structures,drinking purified water,and frequent heartburn symptoms,while negatively correlated with the use of refrigerators and following a regular eating schedule.A larger living area was an independent protective factor for H.pylori infection in households.Frequently consuming excessively hot food and symptoms of halitosis were independent risk factors for H.pylori infection in individuals;frequent consumption of nuts was an independent protective factor for H.pylori infection.Other types of family structure,drinking purified water,and frequent heartburn symptoms were

关 键 词：Helicobacter pylori HOUSEHOLD China PREVALENCE Risk factors 

分 类 号：R573.3[医药卫生—消化系统] R735.34[医药卫生—内科学]