Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease  

作　　者：Davide Ramoni Luca Liberale Fabrizio Montecucco 

机构地区：[1]Department of Internal Medicine,University of Genoa,Genoa 16132,Italy [2]Department of Internal Medicine,First Clinic of Internal Medicine,IRCCS Ospedale Policlinico San Martino,Italian Cardiovascular Network,Genoa 16132,Italy

出　　处：《World Journal of Gastroenterology》2024年第47期5086-5091,共6页世界胃肠病学杂志（英文）

摘　　要：Qu and Li emphasize a fundamental aspect of metabolic dysfunction-associated fatty liver disease in their manuscript,focusing on the critical need for noninvasive diagnostic tools to improve risk stratification and predict the progression to severe liver complications.Affecting approximately 25%of the global population,metabolic dysfunction-associated fatty liver disease is the most common chronic liver condition,with higher prevalence among those with obesity.This letter stresses the importance of early diagnosis and intervention,especially given the rising incidence of obesity and metabolic syndrome.Research advancements provide insight into the potential of biomarkers(particularly inflammationrelated)as predictive tools for disease progression and treatment response.This overview addresses pleiotropic biomarkers linked to chronic inflammation and cardiometabolic disorders,which may aid in risk stratification and treatment efficacy monitoring.Despite progress,significant knowledge gaps remain in the clinical application of these biomarkers,necessitating further research to establish standardized protocols and validate their utility in clinical practice.Understanding the complex interactions among these factors opens new avenues to enhance risk assessment,leading to better patient outcomes and addressing the public health burden of this worldwide condition.

关 键 词：ADIPOKINES Cardiometabolic risk assessment Inflammatory biomarkers Metabolic dysfunction-associated fatty liver disease Metabolic syndrome OSTEOPONTIN 

分 类 号：R563.1[医药卫生—呼吸系统] R575.5[医药卫生—内科学]