E-cigarettes and arterial health:A review of the link between vaping and atherosclerosis progression  

作　　者：Muhammad Hassan Julia Vinagolu-Baur Vivian Li Kelly Frasier Grace Herrick Tiffany Scotto Erica Rankin 

机构地区：[1]Department of Medicine,Nuvance Health,Vassar Brothers Medical Center,Poughkeepsie,NY 12601,United States [2]Department of Medical Education,State University of New York,Upstate Medical University,Syracuse,NY 13210,United States [3]Department of Medical Education,Alabama College of Osteopathic Medicine,Dothan,AL 36303,United States [4]Department of Medicine,University of Florida Health,Jacksonville,FL 32209,United States [5]Department of Medical Education,Nova Southeastern University Kiran C.Patel College of Osteopathic Medicine,Fort Lauderdale,FL 33328,United States

出　　处：《World Journal of Cardiology》2024年第12期707-719,共13页世界心脏病学杂志（英文）

摘　　要：Recent studies have suggested an evolving understanding of the association be-tween vaping,specifically electronic cigarette(e-cigarette)use,and the progre-ssion of atherosclerosis,a significant contributor to cardiovascular disease.Des-pite the prevailing perception of vaping as a safer alternative to traditional toba-cco smoking,accumulating evidence suggests that the aerosols emitted by e-cigarettes contain harmful constituents that may promote endothelial dysfunction,oxidative stress,inflammation,and dyslipidemia—key mechanisms implicated in atherosclerosis pathogenesis.While past research,including experimental studies and clinical investigations,has shed light on the potential cardiovascular risks associated with vaping,gaps in knowledge persist.Future research endeavors should focus on interpreting the long-term effects of vaping on atherosclerosis development and progression,exploring the impact of different e-cigarette formu-lations and user demographics,and identifying effective strategies for mitigating the cardiovascular consequences of vaping.By identifying and addressing these research gaps,we can enhance our understanding of the cardiovascular implica-tions of vaping and inform evidence-based interventions and policies to safe-guard public health.Core Tip:E-cigarette use has been linked to various cardiovascular risks,including the progression of atherosclerosis.Despite the perception of vaping as a safer alternative to smoking,evidence suggests that e-cigarette aerosols contain harmful substances that contribute to endothelial dysfunction,oxidative stress,inflammation,and dyslipidemia.These mechanisms are crucial in the development and progression of atherosclerosis.This review explores multiple facets of e-cigarettes and arterial health,focusing on the connection between vaping and atherosclerosis progression.It presents up-to-date evidence on pathophysiology and significant clinical implications,the impact of various constituents,and discusses contemporary public health strategies.

关 键 词：E-cigarettes Vaping ATHEROSCLEROSIS Cardiovascular disease DYSLIPIDEMIA Oxidative stress Nicotine 

分 类 号：R543.3[医药卫生—心血管疾病]