Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease  

作　　者：Supriti Patnaik Siva Sundara Kumar Durairajan Abhay Kumar Singh Senthilkumar Krishnamoorthi Ashok Iyaswamy Shiva Prasad Mandavi Rajesh Jeewon Leonard L Williams 

机构地区：[1]Molecular Mycology and Neurodegenerative Disease Research Laboratory,Department of Microbiology,Central University of Tamil Nadu,Thiruvarur 610005,India [2]School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong SAR,China [3]Mr.&Mrs Ko Chi-Ming Centre for Parkinson’s Disease Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong SAR,China [4]Department of Biochemistry,Karpagam Academy of Higher Education,Coimbatore 641021,India [5]Department of Chemistry,Central University of Tamil Nadu,Tiruvarur 610005,India [6]Department of Health Sciences,Faculty of Medicine and Health Sciences,University of Mauritius,Reduit 80837,Mauritius [7]Department of Zoology,College of Science,King Saud University,Riyadh 11451,Saudi Arabia [8]Center for Excellence in Post Harvest Technologies,North Carolina Agricultural and Technical State University,The North Carolina Research Campus,Kannapolis,NC 28081,United States

出　　处：《World Journal of Gastroenterology》2024年第48期5212-5220,共9页世界胃肠病学杂志（英文）

摘　　要：The gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease(IBD).While research has focused on the bacterial microbiome,recent studies have shifted towards host genetics and host-fungal interactions.The mycobiota is a vital component of the gastrointestinal microbial community and plays a significant role in immune regulation.Among fungi,Candida species,particularly Candida albicans(C.albicans),have been extensively studied due to their dual role as gut commensals and invasive pathogens.Recent findings indicate that various strains of C.albicans exhibit consid-erable differences in virulence factors,impacting IBD's pathophysiology.Intestinal fungal dysbiosis and antifungal mucosal immunity may be associated to IBD,especially Crohn's disease(CD).This article discusses intestinal fungal dysbiosis and antifungal immunity in healthy individuals and CD patients.It discusses factors influencing the mycobiome's role in IBD pathogenesis and highlights significant contributions from the scientific community aimed at enhancing understanding of the mycobiome and encouraging further research and targeted intervention studies on specific fungal populations.Our article also provided insights into a recent study by Wu et al in the World Journal of Gastroenterology regarding the role of the gut microbiota in the pathogenesis of CD.

关 键 词：Inflammatory bowel disease Ulcerative colitis Crohn's disease Gut mycobiome dysbiosis Candida species Immune regulation Gut inflammation Fecal mycobiota transplantation 

分 类 号：R574.62[医药卫生—消化系统]