Exploring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies  

作　　者：Tong Qiao Xian-Hui Wen 

机构地区：[1]Department of Clinical Medicine,Jinan University,Guangzhou 510632,Guangdong Province,China [2]College of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong Province,China

出　　处：《World Journal of Gastroenterology》2025年第2期147-156,共10页世界胃肠病学杂志（英文）

摘　　要：Extensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental triggers.Recently,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of CD.This paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and exploring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic diets.Creeping fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut microbiome.We characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD pathogenesis.Additionally,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary interventions.By elucidating the complex interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关 键 词：Crohn’s disease Gut microbiome DYSBIOSIS Creeping fat Fecal microbiota transplantation 

分 类 号：R656.9[医药卫生—外科学]