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作 者:Ming-Hua Zheng Amedeo Lonardo
机构地区:[1]Department of Hepatology,MAFLD Research Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China [2]Department of Internal Medicine,Azienda Ospedaliero-Universitaria of Modena(2023),Modena 41126,Italy
出 处:《World Journal of Gastroenterology》2025年第3期1-10,共10页世界胃肠病学杂志(英文)
摘 要:Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical decisions.The paper published by Dallio et al reports on red cell distribution width(RDW)/platelet ratio(RPR)as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease(MASLD)-related cACLD.Differently from other biomarkers and algorithms,RPR is inexpensive and widely available,based on parameters which are included in a complete blood count.RPR is computed on the grounds of two different items,one of which,RDW,mirrors the host’s response to a variety of disease stimuli and is non-specific.The second parameter involved in RPR,platelet count,is more specific and has been used in the hepatological clinic to discriminate cirrhotic from non-cirrhotic chronic liver disease for decades.Cardiovascular disease is the primary cause of mortality among MASLD subjects,followed by extra-hepatic cancers and liver-related mortality.Therefore,MASLD biomarkers should be validated not only in terms of liver-related events but also in the prediction of major adverse cardiovascular events and cardiovascular mortality and extra-hepatic cancers.Adequately sized multi-ethnic confirmatory investigation is required to define the role and significance of RPR in the stratification of MASLD-cACLD.
关 键 词:Cirrhosis Liver fibrosis Natural course PROGNOSTICATION STRATIFICATION
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