Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease  

作　　者：Hao Ding Yuan-Yuan Fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China [2]Department of Radiation Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China [3]Department of Gastroenterology,Suzhou First People's Hospital,Suzhou 234099,Anhui Province,China

出　　处：《World Journal of Gastroenterology》2025年第3期62-72,共11页世界胃肠病学杂志（英文）

基　　金：Supported by Natural Science Foundation of Anhui Medical University,No.2023xkj130.

摘　　要：BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD patients.Yet,it poses a significant challenge due to its limited accessibility through conventional endoscopic methods.AIM To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD patients.METHODS Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic model.Patient demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic features.The diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),respectively.RESULTS Of the 73 patients enrolled,25 patients achieved MH.The radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by DCA.CONCLUSION These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关 键 词：Crohn’s disease Computed tomography enterography Mucosal healing NOMOGRAM Radiomics 

分 类 号：R574[医药卫生—消化系统]