Unraveling the landscape of pediatric pancreatic tumors:Insights from Japan  

作　　者：Savvas Lampridis 

机构地区：[1]Faculty of Medicine,Imperial College London,London SW72AZ,United Kingdom [2]Department of Surgical Oncology,424 General Military Training Hospital,Thessaloniki 56429,Greece

出　　处：《World Journal of Gastrointestinal Oncology》2025年第1期34-38,共5页世界胃肠肿瘤学杂志（英文）

摘　　要：Pediatric pancreatic tumors,though rare,pose significant diagnostic and manage-ment challenges.The recent,22-year nationwide survey on pediatric pancreatic tumors in Japan by Makita et al offers valuable insights into this uncommon enti-ty,revealing striking geographical variations and questioning current treatment paradigms.This editorial commentary analyzes the study's key findings,inclu-ding the predominance of solid pseudopapillary neoplasms and their younger age of onset,which contrast sharply with Western data.It explores the implications for clinical practice and research,emphasizing the need for population-specific approaches to diagnosis and treatment.The revealed limited institutional expe-rience and surgical management patterns prompt a reevaluation of optimal care delivery for these complex cases,suggesting benefits of centralizing healthcare services.Furthermore,the commentary advocates for international collaborative studies to elucidate the genetic,environmental,and lifestyle factors influencing the development and progression of pediatric pancreatic tumors across diverse populations.It also outlines future directions,calling for advancements in precision medicine and innovative care delivery models to improve global patient outcomes.Unraveling Makita et al's findings within the broader landscape of pediatric oncology can stimulate further research and clinical advancements in managing pancreatic and other rare tumors in children.

关 键 词：CHILD EPIDEMIOLOGY JAPAN Pancreatic endocrine tumors Pancreatic neoplasms PANCREATOBLASTOMA Pediatric oncology Solid pseudopapillary neoplasm Surgical management Survey 

分 类 号：R735.9[医药卫生—肿瘤]