Controversies around the treatment of peritoneal metastases of colorectal cancer  

作　　者：Francisco J Morera-Ocon Clara Navarro-Campoy Ticiano Guastella Francisco Landete-Molina 

机构地区：[1]Department of General Surgery,Hospital General de Requena,Requena 46340,Spain [2]Department of Gynecology and Obstetrics,Hospital 9 Octubre,Valencia 46015,Spain [3]Department of Pathology,Hospital General de Requena,Requena 46340,Spain

出　　处：《World Journal of Gastrointestinal Oncology》2025年第1期260-264,共5页世界胃肠肿瘤学杂志（英文）

摘　　要：In this editorial we examine the article by Wu et al published in the World Journal of Gastrointestinal Oncology.Surgical resection for peritoneal metastases from colorectal cancer(CRC)has been gradually accepted in the medical oncology community.A randomized trial(PRODIGE 7)on cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal origin.Nevertheless,isolated systemic chemotherapy for CRC stage IV has demonstrated a reduced response in peritoneal metastases than that obtained in other metastatic sites such as the liver.Another tool is required in those patients to achieve more local control of the disease.Surgical groups in peritoneal surgery continue to use HIPEC in their procedures,using other agents than oxaliplatin for peritoneal cavity infusion,such as mitomycin C.These patients present with complex surgical issues to manage,and consequently a large burden of complications has to be anticipated.Therefore,identifying patients who will benefit from CRS with or without HIPEC would be of great interest.

关 键 词：Colorectal cancer Peritoneal metastasis Hyperthermic intraoperative chemotherapy Treatment strategies Peritoneal Surface Oncology GroupInternational 

分 类 号：R73-37[医药卫生—肿瘤]