Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions  

作　　者：Xin-Yue Wei Wen-Bo Cao Sai-Jun Mo Zhi-Yan Sun 

机构地区：[1]Department of Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,Henan Province,China [2]School of Basic Medical Science,Zhengzhou University,Zhengzhou 450001,Henan Province,China [3]Department of Basic Science of Oncology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,Henan Province,China [4]Department of Special Service,No.988 Hospital of the Joint Service Support Force of PLA,Zhengzhou 450042,Henan Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第1期265-267,共3页世界胃肠肿瘤学杂志（英文）

基　　金：Supported by The College Students’Innovation and Entrepreneurship Competition,No.2024cxcy504 and No.202410459164.

摘　　要：The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC targets.Key genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC patients.Molecular docking con-firmed strong binding affinity of curcumin to these genes.In vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关 键 词：CURCUMIN Gastric cancer Network pharmacology Mechanism of action In vitro experiments 

分 类 号：R730.5[医药卫生—肿瘤]