Effect of hyperthermia combined with opioids on cancer pain control and surgical stress in patients with gastrointestinal cancer  

作　　者：Jing Qian Jing Wu Jing Zhu Jie Qiu Chuan-Fu Wu Cheng-Ru Hu 

机构地区：[1]Department of Oncology,Suzhou Ninth People's Hospital,Suzhou 215200,Jiangsu Province,China [2]Department of Gastrointestinal Surgery,Suzhou Ninth People's Hospital,Suzhou 215200,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第12期3745-3753,共9页世界胃肠外科杂志（英文）

摘　　要：BACKGROUND Surgical palliative surgery is a common method for treating patients with middle and late stage gastrointestinal tumors.However,these patients generally expe-rience high levels of cancer pain,which can in turn stimulate the body’s stress and undermine the effect of external surgery.Although opioid drugs have a signifi-cantly positive effect on controlling cancer pain,they can induce adverse drug reactions and potential damage to the body’s immune function.Hyperthermia therapy produces a thermal effect that shrinks tumor tissues.However,its effect on relieving the pain of middle and late stage gastrointestinal tumors but also the stress of surgical palliative surgery remains unclear.AIM To investigate the effect of hyperthermia combined with opioids on controlling cancer pain in patients with middle and late stage gastrointestinal cancer and evaluate its impact on surgical palliative surgical stress.METHODS This was a retrospective study using the data of 70 patients with middle and late stage gastrointestinal tumors who underwent cancer pain treatment and surgical palliative surgery in the Ninth People’s Hospital of Suzhou,China from January 2021 to June 2024.Patients were grouped according to different cancer pain control regimens before surgical palliative surgery,with n=35 cases in each group,as follows:Patients who solely used opioid drugs to control cancer pain were included in Group S,while patients who received hyperthermia treatment combined with opioid drugs were included in Group L.In both groups,we compared the effectiveness of cancer pain control(pain score,burst pain score,24-hour burst pain frequency,immune function,daily dosage of opioid drugs,and adverse reactions),surgical palliative indicators(surgery time,intraoperative bleeding,stress response),and postoperative recovery time,including first oral feeding time,postoperative hospital stay).RESULTS Analgesic treatment resulted in a significant decrease in the average pain score,burst pain score,and 24-hour burst pain frequency in

关 键 词：Thermal therapy Opioid drugs Gastrointestinal tumors Cancer pain Surgical operation 

分 类 号：R735.2[医药卫生—肿瘤]